Association Between Sarcopenic Obesity and Falls in a Multiethnic Cohort of Postmenopausal Women

Shawna Follis, Alan Cook, Jennifer W Bea, Scott B Going, Deepika Laddu, Jane A. Cauley, Aladdin H. Shadyab, Marcia L. Stefanick, Zhao Chen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVES: To investigate associations between sarcopenia, obesity, and sarcopenic obesity and incidence of falls in a racially and ethnically diverse cohort of healthy postmenopausal women. DESIGN: Prospective cohort study. SETTING: Three Women's Health Initiative (WHI) clinical centers (Tucson-Phoenix, AZ; Pittsburgh, PA; Birmingham, AL). PARTICIPANTS: Postmenopausal women aged 50 to 79 enrolled in the WHI who underwent bone and body composition scans using dual-energy x-ray absorptiometry at baseline (N = 11,020). MEASUREMENTS: Sarcopenia was defined as the lowest 20th percentile of appendicular lean mass, correcting for height and body fat. Obesity was defined as a body fat percentage greater than 42%. Sarcopenic obesity was defined as co-occurrence of sarcopenia and obesity. The fall outcome was defined as falling 2 or more times in any year during 7 years of follow-up. The risk of falls associated with sarcopenic obesity were analyzed using log binomial regression models stratified according to age and race/ethnicity. Results: Sarcopenic obesity was associated with greater risk of falls in women aged 50 to 64 (relative risk (RR) = 1.35, 95% confidence interval (CI)=1.17–1.56) and 65 to 79 (RR = 1.21, 95% CI=1.05–1.39). Sarcopenic obesity related fall risk was higher in Hispanic women (RR = 2.40, 95% CI=1.56–3.67) than non-Hispanic white women (RR = 1.24, 95% CI=1.11–1.39). Conclusion: In a multiethnic cohort of postmenopausal women, sarcopenic obesity–related fall risk was high in women younger than 65 and those age 65 and older. Sarcopenic obesity posed the highest risk for falls in Hispanic women. The findings support identification of causal factors and health disparities in sarcopenic obesity to customize fall prevention strategies and ameliorate this significant public health burden.

Original languageEnglish (US)
JournalJournal of the American Geriatrics Society
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Obesity
Sarcopenia
Confidence Intervals
Women's Health
Hispanic Americans
Adipose Tissue
Accidental Falls
Statistical Models
Body Composition
Cohort Studies
Public Health
X-Rays
Prospective Studies
Bone and Bones
Incidence
Health

Keywords

  • falls
  • obesity
  • race
  • sarcopenia
  • Women's Health Initiative

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Association Between Sarcopenic Obesity and Falls in a Multiethnic Cohort of Postmenopausal Women. / Follis, Shawna; Cook, Alan; Bea, Jennifer W; Going, Scott B; Laddu, Deepika; Cauley, Jane A.; Shadyab, Aladdin H.; Stefanick, Marcia L.; Chen, Zhao.

In: Journal of the American Geriatrics Society, 01.01.2018.

Research output: Contribution to journalArticle

Follis, Shawna ; Cook, Alan ; Bea, Jennifer W ; Going, Scott B ; Laddu, Deepika ; Cauley, Jane A. ; Shadyab, Aladdin H. ; Stefanick, Marcia L. ; Chen, Zhao. / Association Between Sarcopenic Obesity and Falls in a Multiethnic Cohort of Postmenopausal Women. In: Journal of the American Geriatrics Society. 2018.
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abstract = "OBJECTIVES: To investigate associations between sarcopenia, obesity, and sarcopenic obesity and incidence of falls in a racially and ethnically diverse cohort of healthy postmenopausal women. DESIGN: Prospective cohort study. SETTING: Three Women's Health Initiative (WHI) clinical centers (Tucson-Phoenix, AZ; Pittsburgh, PA; Birmingham, AL). PARTICIPANTS: Postmenopausal women aged 50 to 79 enrolled in the WHI who underwent bone and body composition scans using dual-energy x-ray absorptiometry at baseline (N = 11,020). MEASUREMENTS: Sarcopenia was defined as the lowest 20th percentile of appendicular lean mass, correcting for height and body fat. Obesity was defined as a body fat percentage greater than 42{\%}. Sarcopenic obesity was defined as co-occurrence of sarcopenia and obesity. The fall outcome was defined as falling 2 or more times in any year during 7 years of follow-up. The risk of falls associated with sarcopenic obesity were analyzed using log binomial regression models stratified according to age and race/ethnicity. Results: Sarcopenic obesity was associated with greater risk of falls in women aged 50 to 64 (relative risk (RR) = 1.35, 95{\%} confidence interval (CI)=1.17–1.56) and 65 to 79 (RR = 1.21, 95{\%} CI=1.05–1.39). Sarcopenic obesity related fall risk was higher in Hispanic women (RR = 2.40, 95{\%} CI=1.56–3.67) than non-Hispanic white women (RR = 1.24, 95{\%} CI=1.11–1.39). Conclusion: In a multiethnic cohort of postmenopausal women, sarcopenic obesity–related fall risk was high in women younger than 65 and those age 65 and older. Sarcopenic obesity posed the highest risk for falls in Hispanic women. The findings support identification of causal factors and health disparities in sarcopenic obesity to customize fall prevention strategies and ameliorate this significant public health burden.",
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AU - Follis, Shawna

AU - Cook, Alan

AU - Bea, Jennifer W

AU - Going, Scott B

AU - Laddu, Deepika

AU - Cauley, Jane A.

AU - Shadyab, Aladdin H.

AU - Stefanick, Marcia L.

AU - Chen, Zhao

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N2 - OBJECTIVES: To investigate associations between sarcopenia, obesity, and sarcopenic obesity and incidence of falls in a racially and ethnically diverse cohort of healthy postmenopausal women. DESIGN: Prospective cohort study. SETTING: Three Women's Health Initiative (WHI) clinical centers (Tucson-Phoenix, AZ; Pittsburgh, PA; Birmingham, AL). PARTICIPANTS: Postmenopausal women aged 50 to 79 enrolled in the WHI who underwent bone and body composition scans using dual-energy x-ray absorptiometry at baseline (N = 11,020). MEASUREMENTS: Sarcopenia was defined as the lowest 20th percentile of appendicular lean mass, correcting for height and body fat. Obesity was defined as a body fat percentage greater than 42%. Sarcopenic obesity was defined as co-occurrence of sarcopenia and obesity. The fall outcome was defined as falling 2 or more times in any year during 7 years of follow-up. The risk of falls associated with sarcopenic obesity were analyzed using log binomial regression models stratified according to age and race/ethnicity. Results: Sarcopenic obesity was associated with greater risk of falls in women aged 50 to 64 (relative risk (RR) = 1.35, 95% confidence interval (CI)=1.17–1.56) and 65 to 79 (RR = 1.21, 95% CI=1.05–1.39). Sarcopenic obesity related fall risk was higher in Hispanic women (RR = 2.40, 95% CI=1.56–3.67) than non-Hispanic white women (RR = 1.24, 95% CI=1.11–1.39). Conclusion: In a multiethnic cohort of postmenopausal women, sarcopenic obesity–related fall risk was high in women younger than 65 and those age 65 and older. Sarcopenic obesity posed the highest risk for falls in Hispanic women. The findings support identification of causal factors and health disparities in sarcopenic obesity to customize fall prevention strategies and ameliorate this significant public health burden.

AB - OBJECTIVES: To investigate associations between sarcopenia, obesity, and sarcopenic obesity and incidence of falls in a racially and ethnically diverse cohort of healthy postmenopausal women. DESIGN: Prospective cohort study. SETTING: Three Women's Health Initiative (WHI) clinical centers (Tucson-Phoenix, AZ; Pittsburgh, PA; Birmingham, AL). PARTICIPANTS: Postmenopausal women aged 50 to 79 enrolled in the WHI who underwent bone and body composition scans using dual-energy x-ray absorptiometry at baseline (N = 11,020). MEASUREMENTS: Sarcopenia was defined as the lowest 20th percentile of appendicular lean mass, correcting for height and body fat. Obesity was defined as a body fat percentage greater than 42%. Sarcopenic obesity was defined as co-occurrence of sarcopenia and obesity. The fall outcome was defined as falling 2 or more times in any year during 7 years of follow-up. The risk of falls associated with sarcopenic obesity were analyzed using log binomial regression models stratified according to age and race/ethnicity. Results: Sarcopenic obesity was associated with greater risk of falls in women aged 50 to 64 (relative risk (RR) = 1.35, 95% confidence interval (CI)=1.17–1.56) and 65 to 79 (RR = 1.21, 95% CI=1.05–1.39). Sarcopenic obesity related fall risk was higher in Hispanic women (RR = 2.40, 95% CI=1.56–3.67) than non-Hispanic white women (RR = 1.24, 95% CI=1.11–1.39). Conclusion: In a multiethnic cohort of postmenopausal women, sarcopenic obesity–related fall risk was high in women younger than 65 and those age 65 and older. Sarcopenic obesity posed the highest risk for falls in Hispanic women. The findings support identification of causal factors and health disparities in sarcopenic obesity to customize fall prevention strategies and ameliorate this significant public health burden.

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