Association between serum 25-hydroxy-vitamin D and aggressive prostate cancer in African American men

Shakira M. Nelson, Ken Batai, Chiledum Ahaghotu, Tanya Agurs-Collins, Rick A. Kittles

Research output: Research - peer-reviewArticle

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Abstract

African American men have higher incidence rates of aggressive prostate cancer, where high levels of calcium and serum vitamin D deficient levels play a role in the racial differences in incidence. In this study, we examined associations of serum vitamin D with aggressive prostate cancer to improve our understanding of higher susceptibility of aggressive disease in this racial cohort. From Howard University Hospital, 155 African American men with clinically-identified prostate cancer were identified, 46 aggressive cases, and 58 non-aggressive cases. Serum vitamin D was assessed from fasting blood samples, and total calcium intake was assessed using the Block Food Frequency Questionnaire. Vitamin D receptor polymorphisms from three different loci were genotyped, rs731236, rs1544410, and rs11568820. Multivariate logistic regression models were used to determine odds ratios (OR) and 95% confidence intervals (CI) comparing aggressive to non-aggressive prostate cancer. Vitamin D deficiency (<20 ng/mL) significantly increased risk of aggressive disease (OR: 3.1, 95% CI: 1.03-9.57, p-value = 0.04). Stratification by total calcium showed high calcium levels (≥800 mg/day) modified this association (OR: 7.3, 95% CI: 2.15-47.68, p-interaction = 0.03). Genetic variant rs11568820 appeared to increase the magnitude of association between deficient serum vitamin D and aggressive prostate cancer (OR: 3.64, 95% CI: 1.12-11.75, p-value = 0.05). These findings suggest that high incidence of aggressive prostate cancer risk in African American men may be due in-part to deficient levels of serum vitamin D. Other factors, including genetics, should be considered for future studies.

LanguageEnglish (US)
Article number12
JournalNutrients
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

prostatic neoplasms
African Americans
vitamin D
blood serum
Vitamin D
Prostatic Neoplasms
Serum
odds ratio
confidence interval
calcium
Odds Ratio
Confidence Intervals
Calcium
incidence
Incidence
Logistic Models
vitamin D deficiency
food frequency questionnaires
fasting
genetic polymorphism

Keywords

  • African American men
  • Aggressive prostate cancer
  • Calcium
  • Rs11568820
  • Serum 25-hydroxyvitamin D
  • Vitamin D receptor small nucleotide polymorphisms

ASJC Scopus subject areas

  • Food Science

Cite this

Association between serum 25-hydroxy-vitamin D and aggressive prostate cancer in African American men. / Nelson, Shakira M.; Batai, Ken; Ahaghotu, Chiledum; Agurs-Collins, Tanya; Kittles, Rick A.

In: Nutrients, Vol. 9, No. 1, 12, 01.01.2017.

Research output: Research - peer-reviewArticle

Nelson SM, Batai K, Ahaghotu C, Agurs-Collins T, Kittles RA. Association between serum 25-hydroxy-vitamin D and aggressive prostate cancer in African American men. Nutrients. 2017 Jan 1;9(1). 12. Available from, DOI: 10.3390/nu9010012
Nelson, Shakira M. ; Batai, Ken ; Ahaghotu, Chiledum ; Agurs-Collins, Tanya ; Kittles, Rick A./ Association between serum 25-hydroxy-vitamin D and aggressive prostate cancer in African American men. In: Nutrients. 2017 ; Vol. 9, No. 1.
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