Association of dynamics in lean and fat mass measures with mortality in frail older women

Oleg Zaslavsky, E. Rillamas-Sun, W. Li, S. Going, M. Datta, L. Snetselaar, S. Zelber-Sagi

Research output: Research - peer-reviewArticle

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Abstract

Objective: The relationship between body composition and mortality in frail older people is unclear. We used dual-x-ray absorptiometry (DXA) data to examine the association between dynamics in whole-body composition and appendicular (4 limbs) and central (trunk) compartments and all-cause mortality in frail older women. Design: Prospective study with up to 19 years of follow up. Setting: Community dwelling older (≥65) women. Participants: 876 frail older participants of the Women’s Health Initiative Observational Study with a single measure of body composition and 581 participants with two measures. Measurements: Frailty was determined using modified Fried’s criteria. All-cause mortality hazard was modeled as a function of static (single-occasion) or dynamic changes (difference between two time points) in body composition using Cox regression. Results: Analyses adjusted for age, ethnicity, income, smoking, cardiovascular disease, diabetes, stroke, number of frailty criteria and whole-body lean mass showed progressively decreased rates of mortality in women with higher appendicular fat mass (FM) (P for trend=0.01), higher trunk FM (P for trend=0.03) and higher whole-body FM (P for trend=0.01). The hazard rate ratio for participants with more than a 5% decline in FM between two time points was 1.91; 1.67 and 1.71 for appendicular, trunk and whole-body compartment respectively as compared to women with relatively stable adiposity (p<0.05 for all). Dynamics of more than 5% in lean mass were not associated with mortality. Conclusion: Low body fat or a pronounced decline in adiposity is associated with increased risks of mortality in frail older women. These results indicate a need to re-evaluate healthy weight in persons with frailty.

LanguageEnglish (US)
Pages112-119
Number of pages8
JournalJournal of Nutrition, Health and Aging
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Fats
Mortality
Body Composition
Adiposity
Adipose Tissue
Independent Living
Women's Health
Observational Studies
Cardiovascular Diseases
Extremities
Smoking
Stroke
X-Rays
Prospective Studies
Weights and Measures

Keywords

  • body composition
  • fat mass
  • Frailty
  • lean mass
  • mortality

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Geriatrics and Gerontology

Cite this

Zaslavsky, O., Rillamas-Sun, E., Li, W., Going, S., Datta, M., Snetselaar, L., & Zelber-Sagi, S. (2017). Association of dynamics in lean and fat mass measures with mortality in frail older women. Journal of Nutrition, Health and Aging, 21(1), 112-119. DOI: 10.1007/s12603-016-0730-1

Association of dynamics in lean and fat mass measures with mortality in frail older women. / Zaslavsky, Oleg; Rillamas-Sun, E.; Li, W.; Going, S.; Datta, M.; Snetselaar, L.; Zelber-Sagi, S.

In: Journal of Nutrition, Health and Aging, Vol. 21, No. 1, 01.01.2017, p. 112-119.

Research output: Research - peer-reviewArticle

Zaslavsky, O, Rillamas-Sun, E, Li, W, Going, S, Datta, M, Snetselaar, L & Zelber-Sagi, S 2017, 'Association of dynamics in lean and fat mass measures with mortality in frail older women' Journal of Nutrition, Health and Aging, vol 21, no. 1, pp. 112-119. DOI: 10.1007/s12603-016-0730-1
Zaslavsky O, Rillamas-Sun E, Li W, Going S, Datta M, Snetselaar L et al. Association of dynamics in lean and fat mass measures with mortality in frail older women. Journal of Nutrition, Health and Aging. 2017 Jan 1;21(1):112-119. Available from, DOI: 10.1007/s12603-016-0730-1
Zaslavsky, Oleg ; Rillamas-Sun, E. ; Li, W. ; Going, S. ; Datta, M. ; Snetselaar, L. ; Zelber-Sagi, S./ Association of dynamics in lean and fat mass measures with mortality in frail older women. In: Journal of Nutrition, Health and Aging. 2017 ; Vol. 21, No. 1. pp. 112-119
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