Association of interleukin-2 and interferon-γ production by blood mononuclear cells in infancy with parental allergy skin tests and with subsequent development of atopy

Fernando Martinez, Debra A. Stern, Anne L Wright, Catharine J. Holberg, Lynn M. Taussig, Marilyn Halonen

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

The mechanisms regulating the onset of atopic sensitization in human beings are not yet fully clarified. We assessed the capacity of mitogen-stimulated umbilical and peripheral blood mononuclear cells to produce interferon-γ (IFN-γ) and interleukin-2 (IL-2) at birth and at 9 months of age in 159 infants. Mononuclear cell production of both IFN-γ and IL-2 at 9 months, but not at birth, was found to be inversely related to parental immediate skin test reactivity to seven local aeroallergens. Skin test reactivity at the age of 6 years was also inversely related to IFN-γ and IL-2 production at 9 months of age. However, no relationship was evident between total serum IgE levels at 6 years and production of these cytokines at 9 months. The proportions of circulating lymphocytes and CD4+ or CD8+ cells were also unrelated to skin test reactivity at the age of 6 years. These data suggest that mechanisms regulating skin test reactivity to inhaled allergens may involve deficient IFN-γ production, deficient IL-2 production, or both during or preceding the time of initial sensitization and that additional mechanisms are involved in regulating total serum IgE level. (J ALLERGY CLIN IMMUNOL 1995;96:652-60.).

Original languageEnglish (US)
Pages (from-to)652-660
Number of pages9
JournalJournal of Allergy and Clinical Immunology
Volume96
Issue number5
DOIs
StatePublished - 1995

Fingerprint

Skin Tests
Interferons
Interleukin-2
Blood Cells
Hypersensitivity
Immunoglobulin E
Parturition
Umbilicus
Serum
Mitogens
Allergens
Lymphocytes
Cytokines

Keywords

  • allergy skin test
  • cytokines
  • IFN-γ
  • IgE
  • IL-2
  • immediate hypersensitivity
  • infancy
  • T lymphocytes
  • T lymphocytes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Association of interleukin-2 and interferon-γ production by blood mononuclear cells in infancy with parental allergy skin tests and with subsequent development of atopy. / Martinez, Fernando; Stern, Debra A.; Wright, Anne L; Holberg, Catharine J.; Taussig, Lynn M.; Halonen, Marilyn.

In: Journal of Allergy and Clinical Immunology, Vol. 96, No. 5, 1995, p. 652-660.

Research output: Contribution to journalArticle

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AU - Taussig, Lynn M.

AU - Halonen, Marilyn

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