Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study

John W. Winkelman, Eyal Shahar, Imran Sharief, Daniel J. Gottlieb

Research output: Contribution to journalArticle

276 Citations (Scopus)

Abstract

OBJECTIVE: We evaluated the cross-sectional association between restless legs syndrome (RLS) and prevalent cardiovascular disease (CVD) in a large community-based sample of middle-aged and elderly subjects. METHODS: This is a cross-sectional observational study of 1,559 men and 1,874 women (mean age of 67.9 years) who were enrolled in the Sleep Heart Health Study, a community-based study of the cardiovascular consequences of sleep-disordered breathing. RLS was defined by positive responses on a self-administered questionnaire to the four diagnostic criteria, with symptoms occurring at least five times per month and associated with at least moderate distress. Coronary artery disease (CAD) was determined by self-report of doctor-diagnosed angina, myocardial infarction, or coronary revascularization procedure. Total CVD included CAD or history of physician-diagnosed stroke or heart failure. The relation of RLS to prevalent CAD and CVD was examined by multivariable logistic regression models RESULTS: RLS was present in 6.8% of women (n = 128) and 3.3% of men (n = 51). After adjustment for age, sex, race, body mass index, diabetes mellitus, systolic blood pressure, antihypertensive medication use, total:high-density lipoprotein cholesterol ratio, and smoking history, the ORs for CAD were 2.05 (95% CI 1.38 to 3.04) and for CVD were 2.07 (1.43 to 3.00) for subjects with RLS compared to those without RLS. The associations of RLS with CAD and CVD were stronger in those with RLS symptoms at least 16 times per month and were stronger in those with severe than in those with moderately bothersome symptoms. CONCLUSIONS: Restless legs syndrome (RLS) is associated with prevalent coronary artery disease and cardiovascular disease. This association appears stronger in those with greater frequency or severity of RLS symptoms.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalNeurology
Volume70
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Restless Legs Syndrome
Sleep
Cardiovascular Diseases
Health
Coronary Artery Disease
Logistic Models
Blood Pressure
Sleep Apnea Syndromes
Self Report
HDL Cholesterol
Antihypertensive Agents
Observational Studies
Diabetes Mellitus
Body Mass Index
Heart Failure
Cross-Sectional Studies
Smoking
History
Stroke
Myocardial Infarction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study. / Winkelman, John W.; Shahar, Eyal; Sharief, Imran; Gottlieb, Daniel J.

In: Neurology, Vol. 70, No. 1, 01.2008, p. 35-42.

Research output: Contribution to journalArticle

Winkelman, John W. ; Shahar, Eyal ; Sharief, Imran ; Gottlieb, Daniel J. / Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study. In: Neurology. 2008 ; Vol. 70, No. 1. pp. 35-42.
@article{92e354dcce184183b1337a73b318f025,
title = "Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study",
abstract = "OBJECTIVE: We evaluated the cross-sectional association between restless legs syndrome (RLS) and prevalent cardiovascular disease (CVD) in a large community-based sample of middle-aged and elderly subjects. METHODS: This is a cross-sectional observational study of 1,559 men and 1,874 women (mean age of 67.9 years) who were enrolled in the Sleep Heart Health Study, a community-based study of the cardiovascular consequences of sleep-disordered breathing. RLS was defined by positive responses on a self-administered questionnaire to the four diagnostic criteria, with symptoms occurring at least five times per month and associated with at least moderate distress. Coronary artery disease (CAD) was determined by self-report of doctor-diagnosed angina, myocardial infarction, or coronary revascularization procedure. Total CVD included CAD or history of physician-diagnosed stroke or heart failure. The relation of RLS to prevalent CAD and CVD was examined by multivariable logistic regression models RESULTS: RLS was present in 6.8{\%} of women (n = 128) and 3.3{\%} of men (n = 51). After adjustment for age, sex, race, body mass index, diabetes mellitus, systolic blood pressure, antihypertensive medication use, total:high-density lipoprotein cholesterol ratio, and smoking history, the ORs for CAD were 2.05 (95{\%} CI 1.38 to 3.04) and for CVD were 2.07 (1.43 to 3.00) for subjects with RLS compared to those without RLS. The associations of RLS with CAD and CVD were stronger in those with RLS symptoms at least 16 times per month and were stronger in those with severe than in those with moderately bothersome symptoms. CONCLUSIONS: Restless legs syndrome (RLS) is associated with prevalent coronary artery disease and cardiovascular disease. This association appears stronger in those with greater frequency or severity of RLS symptoms.",
author = "Winkelman, {John W.} and Eyal Shahar and Imran Sharief and Gottlieb, {Daniel J.}",
year = "2008",
month = "1",
doi = "10.1212/01.wnl.0000287072.93277.c9",
language = "English (US)",
volume = "70",
pages = "35--42",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Association of restless legs syndrome and cardiovascular disease in the Sleep Heart Health Study

AU - Winkelman, John W.

AU - Shahar, Eyal

AU - Sharief, Imran

AU - Gottlieb, Daniel J.

PY - 2008/1

Y1 - 2008/1

N2 - OBJECTIVE: We evaluated the cross-sectional association between restless legs syndrome (RLS) and prevalent cardiovascular disease (CVD) in a large community-based sample of middle-aged and elderly subjects. METHODS: This is a cross-sectional observational study of 1,559 men and 1,874 women (mean age of 67.9 years) who were enrolled in the Sleep Heart Health Study, a community-based study of the cardiovascular consequences of sleep-disordered breathing. RLS was defined by positive responses on a self-administered questionnaire to the four diagnostic criteria, with symptoms occurring at least five times per month and associated with at least moderate distress. Coronary artery disease (CAD) was determined by self-report of doctor-diagnosed angina, myocardial infarction, or coronary revascularization procedure. Total CVD included CAD or history of physician-diagnosed stroke or heart failure. The relation of RLS to prevalent CAD and CVD was examined by multivariable logistic regression models RESULTS: RLS was present in 6.8% of women (n = 128) and 3.3% of men (n = 51). After adjustment for age, sex, race, body mass index, diabetes mellitus, systolic blood pressure, antihypertensive medication use, total:high-density lipoprotein cholesterol ratio, and smoking history, the ORs for CAD were 2.05 (95% CI 1.38 to 3.04) and for CVD were 2.07 (1.43 to 3.00) for subjects with RLS compared to those without RLS. The associations of RLS with CAD and CVD were stronger in those with RLS symptoms at least 16 times per month and were stronger in those with severe than in those with moderately bothersome symptoms. CONCLUSIONS: Restless legs syndrome (RLS) is associated with prevalent coronary artery disease and cardiovascular disease. This association appears stronger in those with greater frequency or severity of RLS symptoms.

AB - OBJECTIVE: We evaluated the cross-sectional association between restless legs syndrome (RLS) and prevalent cardiovascular disease (CVD) in a large community-based sample of middle-aged and elderly subjects. METHODS: This is a cross-sectional observational study of 1,559 men and 1,874 women (mean age of 67.9 years) who were enrolled in the Sleep Heart Health Study, a community-based study of the cardiovascular consequences of sleep-disordered breathing. RLS was defined by positive responses on a self-administered questionnaire to the four diagnostic criteria, with symptoms occurring at least five times per month and associated with at least moderate distress. Coronary artery disease (CAD) was determined by self-report of doctor-diagnosed angina, myocardial infarction, or coronary revascularization procedure. Total CVD included CAD or history of physician-diagnosed stroke or heart failure. The relation of RLS to prevalent CAD and CVD was examined by multivariable logistic regression models RESULTS: RLS was present in 6.8% of women (n = 128) and 3.3% of men (n = 51). After adjustment for age, sex, race, body mass index, diabetes mellitus, systolic blood pressure, antihypertensive medication use, total:high-density lipoprotein cholesterol ratio, and smoking history, the ORs for CAD were 2.05 (95% CI 1.38 to 3.04) and for CVD were 2.07 (1.43 to 3.00) for subjects with RLS compared to those without RLS. The associations of RLS with CAD and CVD were stronger in those with RLS symptoms at least 16 times per month and were stronger in those with severe than in those with moderately bothersome symptoms. CONCLUSIONS: Restless legs syndrome (RLS) is associated with prevalent coronary artery disease and cardiovascular disease. This association appears stronger in those with greater frequency or severity of RLS symptoms.

UR - http://www.scopus.com/inward/record.url?scp=37849034199&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37849034199&partnerID=8YFLogxK

U2 - 10.1212/01.wnl.0000287072.93277.c9

DO - 10.1212/01.wnl.0000287072.93277.c9

M3 - Article

C2 - 18166705

AN - SCOPUS:37849034199

VL - 70

SP - 35

EP - 42

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 1

ER -