Association of substance use disorders with childhood trauma but not African genetic heritage in an African American cohort

Francesca Ducci, Alec Roy, Pei Hong Shen, Qiaoping Yuan, Nicole P Yuan, Colin A. Hodgkinson, Lynn R. Goldman, David Goldman

Research output: Contribution to journalArticle

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Abstract

Objective: Genetic variation influences differential vulnerability to addiction within populations. However, it remains unclear whether differences in frequencies of vulnerability alleles contribute to disparities between populations and to what extent ancestry correlates with differential exposure to environmental risk factors, including poverty and trauma. Method: The authors used 186 ancestry-informative markers to measure African ancestry in 407 addicts and 457 comparison subjects self-identified as African Americans. The reference group was 1,051 individuals from the Human Genome Diversity Cell Line Panel, which includes 51 diverse populations representing most worldwide genetic diversity. Results: African Americans varied in degrees of African, European, Middle Eastern, and Central Asian genetic heritage. The overall level of African ancestry was actually smaller among cocaine, opiate, and alcohol addicts (proportion=0.76-0.78) than nonaddicted African American comparison subjects (proportion=0.81). African ancestry was associated with living in impoverished neighborhoods, a factor previously associated with risk. There was no association between African ancestry and exposure to childhood abuse or neglect, a factor that strongly predicted all types of addictions. Conclusions: These results suggest that African genetic heritage does not increase the likelihood of genetic risk for addictions. They highlight the complex interrelation between genetic ancestry and social, economic, and environmental conditions and the strong relation of those factors to addiction. Studies of epidemiological samples characterized for genetic ancestry and social, psychological, demographic, economic, cultural, and historical factors are needed to better disentangle the effects of genetic and environmental factors underlying interpopulation differences in vulnerability to addiction and other health disparities.

Original languageEnglish (US)
Pages (from-to)1031-1040
Number of pages10
JournalAmerican Journal of Psychiatry
Volume166
Issue number9
DOIs
StatePublished - Sep 2009
Externally publishedYes

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African Americans
Substance-Related Disorders
Opiate Alkaloids
Wounds and Injuries
Economics
Population
Environmental Exposure
Human Genome
Poverty
Cocaine
Gene Frequency
Epidemiologic Studies
Alcohols
Demography
Psychology
Cell Line
Health

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Association of substance use disorders with childhood trauma but not African genetic heritage in an African American cohort. / Ducci, Francesca; Roy, Alec; Shen, Pei Hong; Yuan, Qiaoping; Yuan, Nicole P; Hodgkinson, Colin A.; Goldman, Lynn R.; Goldman, David.

In: American Journal of Psychiatry, Vol. 166, No. 9, 09.2009, p. 1031-1040.

Research output: Contribution to journalArticle

Ducci, Francesca ; Roy, Alec ; Shen, Pei Hong ; Yuan, Qiaoping ; Yuan, Nicole P ; Hodgkinson, Colin A. ; Goldman, Lynn R. ; Goldman, David. / Association of substance use disorders with childhood trauma but not African genetic heritage in an African American cohort. In: American Journal of Psychiatry. 2009 ; Vol. 166, No. 9. pp. 1031-1040.
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abstract = "Objective: Genetic variation influences differential vulnerability to addiction within populations. However, it remains unclear whether differences in frequencies of vulnerability alleles contribute to disparities between populations and to what extent ancestry correlates with differential exposure to environmental risk factors, including poverty and trauma. Method: The authors used 186 ancestry-informative markers to measure African ancestry in 407 addicts and 457 comparison subjects self-identified as African Americans. The reference group was 1,051 individuals from the Human Genome Diversity Cell Line Panel, which includes 51 diverse populations representing most worldwide genetic diversity. Results: African Americans varied in degrees of African, European, Middle Eastern, and Central Asian genetic heritage. The overall level of African ancestry was actually smaller among cocaine, opiate, and alcohol addicts (proportion=0.76-0.78) than nonaddicted African American comparison subjects (proportion=0.81). African ancestry was associated with living in impoverished neighborhoods, a factor previously associated with risk. There was no association between African ancestry and exposure to childhood abuse or neglect, a factor that strongly predicted all types of addictions. Conclusions: These results suggest that African genetic heritage does not increase the likelihood of genetic risk for addictions. They highlight the complex interrelation between genetic ancestry and social, economic, and environmental conditions and the strong relation of those factors to addiction. Studies of epidemiological samples characterized for genetic ancestry and social, psychological, demographic, economic, cultural, and historical factors are needed to better disentangle the effects of genetic and environmental factors underlying interpopulation differences in vulnerability to addiction and other health disparities.",
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