Association of therapeutic radiation with golgi complex hypertrophy in human urinary bladder carcinomas: Quantitative electron microscopy studies

Joseph Alroy, Bendicht U. Pauli, Ronald S Weinstein

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The volume (Vv) and surface area (surface density; Sv) of the Golgi complex were measured by electron microscopy stereologic techniques in 17 patients with urinary bladder transitional cell carcinomas. Seven patients were irradiated prior to surgical removal, 4 had recurrent carcinomas that arose from previously irradiated bladder urothelium, and the remaining 6 patients had bladder carcinoma but no prior history of therapeutic irradiation. There were significant differences in the Vv and Sv of Golgi complexes per unit of cytoplasmic volume in carcinomas from irradiated and nonirradiated patients (p < 0.01). In carcinomas obtained from irradiated urinary bladders, the Vv was 3.45 ± 0.24% (mean ± SE). In contrast, the Vv was 0.98 ± 0.15% for tumors in the nonirradiated group. Sv values were 1.51 ± 0.09 μm2/μm3 in carcinomas from irradiated bladders, and in the nonirradiated group, the mean Sv was 0.76 ± 0.07 μm2/μm3. These results support the hypothesis that therapeutic irradiation to the urinary bladder induces hyperplasia of Golgi complexes.

Original languageEnglish (US)
Pages (from-to)43-52
Number of pages10
JournalUltrastructural Pathology
Volume2
Issue number1
DOIs
StatePublished - 1981
Externally publishedYes

Fingerprint

bladder
Golgi Apparatus
Hypertrophy
Electron microscopy
electron microscopy
Electron Microscopy
Urinary Bladder
cancer
Irradiation
Radiation
Carcinoma
radiation
Tumors
Cells
Therapeutics
Urothelium
irradiation
Transitional Cell Carcinoma
Hyperplasia
tumors

Keywords

  • Electron microscopy
  • Golgi complex
  • Irradiation
  • Transitional cell carcinoma
  • Urinary bladder

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology
  • Instrumentation

Cite this

@article{75a2944f8f104ecfbe0bc6a4ec76e2b7,
title = "Association of therapeutic radiation with golgi complex hypertrophy in human urinary bladder carcinomas: Quantitative electron microscopy studies",
abstract = "The volume (Vv) and surface area (surface density; Sv) of the Golgi complex were measured by electron microscopy stereologic techniques in 17 patients with urinary bladder transitional cell carcinomas. Seven patients were irradiated prior to surgical removal, 4 had recurrent carcinomas that arose from previously irradiated bladder urothelium, and the remaining 6 patients had bladder carcinoma but no prior history of therapeutic irradiation. There were significant differences in the Vv and Sv of Golgi complexes per unit of cytoplasmic volume in carcinomas from irradiated and nonirradiated patients (p < 0.01). In carcinomas obtained from irradiated urinary bladders, the Vv was 3.45 ± 0.24{\%} (mean ± SE). In contrast, the Vv was 0.98 ± 0.15{\%} for tumors in the nonirradiated group. Sv values were 1.51 ± 0.09 μm2/μm3 in carcinomas from irradiated bladders, and in the nonirradiated group, the mean Sv was 0.76 ± 0.07 μm2/μm3. These results support the hypothesis that therapeutic irradiation to the urinary bladder induces hyperplasia of Golgi complexes.",
keywords = "Electron microscopy, Golgi complex, Irradiation, Transitional cell carcinoma, Urinary bladder",
author = "Joseph Alroy and Pauli, {Bendicht U.} and Weinstein, {Ronald S}",
year = "1981",
doi = "10.3109/01913128109031502",
language = "English (US)",
volume = "2",
pages = "43--52",
journal = "Ultrastructural Pathology",
issn = "0191-3123",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Association of therapeutic radiation with golgi complex hypertrophy in human urinary bladder carcinomas

T2 - Quantitative electron microscopy studies

AU - Alroy, Joseph

AU - Pauli, Bendicht U.

AU - Weinstein, Ronald S

PY - 1981

Y1 - 1981

N2 - The volume (Vv) and surface area (surface density; Sv) of the Golgi complex were measured by electron microscopy stereologic techniques in 17 patients with urinary bladder transitional cell carcinomas. Seven patients were irradiated prior to surgical removal, 4 had recurrent carcinomas that arose from previously irradiated bladder urothelium, and the remaining 6 patients had bladder carcinoma but no prior history of therapeutic irradiation. There were significant differences in the Vv and Sv of Golgi complexes per unit of cytoplasmic volume in carcinomas from irradiated and nonirradiated patients (p < 0.01). In carcinomas obtained from irradiated urinary bladders, the Vv was 3.45 ± 0.24% (mean ± SE). In contrast, the Vv was 0.98 ± 0.15% for tumors in the nonirradiated group. Sv values were 1.51 ± 0.09 μm2/μm3 in carcinomas from irradiated bladders, and in the nonirradiated group, the mean Sv was 0.76 ± 0.07 μm2/μm3. These results support the hypothesis that therapeutic irradiation to the urinary bladder induces hyperplasia of Golgi complexes.

AB - The volume (Vv) and surface area (surface density; Sv) of the Golgi complex were measured by electron microscopy stereologic techniques in 17 patients with urinary bladder transitional cell carcinomas. Seven patients were irradiated prior to surgical removal, 4 had recurrent carcinomas that arose from previously irradiated bladder urothelium, and the remaining 6 patients had bladder carcinoma but no prior history of therapeutic irradiation. There were significant differences in the Vv and Sv of Golgi complexes per unit of cytoplasmic volume in carcinomas from irradiated and nonirradiated patients (p < 0.01). In carcinomas obtained from irradiated urinary bladders, the Vv was 3.45 ± 0.24% (mean ± SE). In contrast, the Vv was 0.98 ± 0.15% for tumors in the nonirradiated group. Sv values were 1.51 ± 0.09 μm2/μm3 in carcinomas from irradiated bladders, and in the nonirradiated group, the mean Sv was 0.76 ± 0.07 μm2/μm3. These results support the hypothesis that therapeutic irradiation to the urinary bladder induces hyperplasia of Golgi complexes.

KW - Electron microscopy

KW - Golgi complex

KW - Irradiation

KW - Transitional cell carcinoma

KW - Urinary bladder

UR - http://www.scopus.com/inward/record.url?scp=0019857956&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019857956&partnerID=8YFLogxK

U2 - 10.3109/01913128109031502

DO - 10.3109/01913128109031502

M3 - Article

C2 - 16830448

AN - SCOPUS:0019857956

VL - 2

SP - 43

EP - 52

JO - Ultrastructural Pathology

JF - Ultrastructural Pathology

SN - 0191-3123

IS - 1

ER -