TY - JOUR
T1 - Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women
AU - Bea, Jennifer W.
AU - Wassertheil-Smoller, Sylvia
AU - Wertheim, Betsy C.
AU - Klimentidis, Yann
AU - Chen, Zhao
AU - Zaslavsky, Oleg
AU - Manini, Todd M.
AU - Womack, Catherine R.
AU - Kroenke, Candyce H.
AU - Lacroix, Andrea Z.
AU - Thomson, Cynthia A.
N1 - Funding Information:
-e WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, and U.S. Department of Health and Human Services through contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C. -e authors are thankful for the contribution of the WHI Investigators and staff at the clinical centers, clinical coordinating center, and project oSce. A short list of WHI investigators is as follows. Program OBce: (National Heart, Lung, and Blood Institute, Bethesda, Maryland) Jacques Rossouw, Shari Ludlam, Joan McGowan, Leslie Ford, and Nancy Geller. Clinical Coordinating Center: Clinical Coordinating Center: (Fred Hutchinson Cancer Research Center, Seattle, WA) Garnet Anderson, Ross Prentice, Andrea LaCroix, and Charles Kooperberg. Investigators and Academic Centers: (Brigham and Women’s Hospital, Harvard Medical School, Boston, MA) JoAnn E. Manson; (MedStar Health Research Institute/ Howard University, Washington, DC) Barbara V. Howard; (Stanford Prevention Research Center, Stanford, CA) Marcia L. Stefanick; (-e Ohio State University, Columbus, OH) Rebecca Jackson; (University of Arizona, Tucson/ Phoenix, AZ) Cynthia A. -omson; (University at Buffalo, Buffalo, NY) Jean Wactawski-Wende; (University of Florida, Gainesville/Jacksonville, FL) Marian Limacher; (University of Iowa, Iowa City/Davenport, IA) Jennifer Robinson; (University of Pittsburgh, Pittsburgh, PA) Lewis Kuller; (Wake Forest University School of Medicine, Winston-Salem, NC) Sally Shumaker; (University of Nevada, Reno, NV) Robert Brunner; (University of Minnesota, Minneapolis, MN) Karen L. Margolis. Women’s Health Initiative Memory Study: (Wake Forest University School of Medicine, Winston-Salem, NC) Mark Espeland. For a list of all the investigators who have contributed to WHI science, please visit www.whi.org/researchers/ Documents%20%20Write%20a%20Paper/WHI%20Investigator %20Long%20List.pdf.
Funding Information:
1University of Arizona Cancer Center, 1515 N. Campbell Ave, P.O. Box 245024, Tucson, AZ 85724-0524, USA 2Department of Epidemiology and Population Health, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Belfer Building, Room 1308B, Bronx, NY 10461, USA 3Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin, P.O. Box 245211, Drachman Hall A238, Tucson, AZ 85724, USA 4Department of Biobehavioral Nursing and Health Systems, University of Washington, P.O Box 357266, 1959 NE Pacific Ave., Seattle, WA 98195-7266, USA 5Department of Aging and Geriatric Research, University of Florida, P.O. Box 100107, Gainesville, FL 32610, USA 6Department of Medicine, University of Tennessee, 956 Court Avenue, Memphis, TN 38163, USA 7Kaiser Permanente Northern California, Division of Research, 2000 Broadway, Oakland, CA 94612, USA 8Department of Family Medicine and Public Health, University of California, 9500 Gilman Drive No. 0725, San Diego, La Jolla, CA 92093, USA 9Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin, P.O. Box 245209, Drachman Hall A260, Tucson, AZ 85724, USA
Publisher Copyright:
© 2018 Jennifer W. Bea et al.
PY - 2018
Y1 - 2018
N2 - Studies suggest that ACE-inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) may preserve skeletal muscle with aging. We evaluated longitudinal differences in lean body mass (LBM) among women diagnosed with hypertension and classified as ACE-I/ARB users and nonusers among Women's Health Initiative participants that received dual energy X-ray absorptiometry scans to estimate body composition (n=10,635) at baseline and at years 3 and 6 of follow-up. Of those, 2642 were treated for hypertension at baseline. Multivariate linear regression models, adjusted for relevant demographics, behaviors, and medications, assessed ACE-I/ARB use/nonuse and LBM associations at baseline, as well as change in LBM over 3 and 6 years. Although BMI did not differ by ACE-I/ARB use, LBM (%) was significantly higher in ACE-I/ARB users versus nonusers at baseline (52.2% versus 51.3%, resp., p=0.001). There was no association between ACE-I/ARB usage and change in LBM over time. Reasons for higher LBM with ACE-I/ARB use cross sectionally, but not longitundinally, are unclear and may reflect a threshold effect of these medications on LBM that is attenuated over time. Nevertheless, ACE-I/ARB use does not appear to negatively impact LBM in the long term.
AB - Studies suggest that ACE-inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) may preserve skeletal muscle with aging. We evaluated longitudinal differences in lean body mass (LBM) among women diagnosed with hypertension and classified as ACE-I/ARB users and nonusers among Women's Health Initiative participants that received dual energy X-ray absorptiometry scans to estimate body composition (n=10,635) at baseline and at years 3 and 6 of follow-up. Of those, 2642 were treated for hypertension at baseline. Multivariate linear regression models, adjusted for relevant demographics, behaviors, and medications, assessed ACE-I/ARB use/nonuse and LBM associations at baseline, as well as change in LBM over 3 and 6 years. Although BMI did not differ by ACE-I/ARB use, LBM (%) was significantly higher in ACE-I/ARB users versus nonusers at baseline (52.2% versus 51.3%, resp., p=0.001). There was no association between ACE-I/ARB usage and change in LBM over time. Reasons for higher LBM with ACE-I/ARB use cross sectionally, but not longitundinally, are unclear and may reflect a threshold effect of these medications on LBM that is attenuated over time. Nevertheless, ACE-I/ARB use does not appear to negatively impact LBM in the long term.
UR - http://www.scopus.com/inward/record.url?scp=85043390044&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043390044&partnerID=8YFLogxK
U2 - 10.1155/2018/8491092
DO - 10.1155/2018/8491092
M3 - Article
AN - SCOPUS:85043390044
VL - 2018
JO - Journal of Aging Research
JF - Journal of Aging Research
SN - 2090-2204
M1 - 8491092
ER -