Associations of fish intake and dietary n-3 polyunsaturated fatty acids with a hypocoagulable profile: The atherosclerosis risk in communities (ARIC) study

Eyal Shahar, Aaron R. Folsom, Kenneth K. Wu, Barbara H. Dennis, Tomoko Shimakawa, Maureen G. Conlan, C. E. Davis, O. Dale Williams

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Recent epidemiological evidence indicates that the hemostatic profile is an important predictor of cardiovascular disease, yet its dietary determinants are not well established. An important question is whether dietary fatty acid intake influences blood levels of coagulation proteins. We examined potential dietary determinants of six hemostatic factors-fibrinogen, factor VII, factor VIII, von Willebrand factor (vWF), protein C, and antithrombin III -in four population-based samples totaling over 15000 participants, blacks and whites, in the Atherosclerosis Risk in Communities (ARIC) Study. Usual dietary intake was assessed by a food frequency questionnaire. Cross-sectional associations were explored using multiple linear regression analysis, adjusting for gender, race, age, body mass index, smoking status, alcohol use, diabetes, and field center. Dietary intake of n-3 polyunsaturated fatty acids (PUFAs) showed negative associations with fibrinogen, factor VIII, and vWF (blacks and whites) and a positive association with protein C (whites only). Fish intake, the major source of dietary n-3 PUFAs, was similarly related to the hemostatic profile: a 1 serving per day greater fish intake was associated with the following predicted differences (95% confidence interval): fibrinogen, -2.9 mg/dL (-6.3, 0.5); factor VIII, -3.3% (-5.4, -1.3); vWF, -2.7% (-5.2, -0.1) (blacks and whites); and protein C, +0.07 μg/mL (0.03, 0.11) (whites only). Other nutrients or foods were variably associated with the hemostatic factors. These population-based associations, although cross-sectional, suggest that increases in n-3 PUFA intake from fish may modify the blood levels of several coagulation factors.

Original languageEnglish (US)
Pages (from-to)1205-1212
Number of pages8
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume13
Issue number8
StatePublished - 1993
Externally publishedYes

Fingerprint

Omega-3 Fatty Acids
Hemostatics
Atherosclerosis
Fishes
Protein C
Fibrinogen
von Willebrand Factor
Food
Factor VII
Blood Coagulation Factors
Antithrombin III
Factor VIII
Blood Coagulation
Population
Linear Models
Body Mass Index
Cardiovascular Diseases
Fatty Acids
Smoking
Regression Analysis

Keywords

  • Blood coagulation factors
  • Factor VIII
  • Fibrinogen
  • Protein C
  • Von willebrand factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Associations of fish intake and dietary n-3 polyunsaturated fatty acids with a hypocoagulable profile : The atherosclerosis risk in communities (ARIC) study. / Shahar, Eyal; Folsom, Aaron R.; Wu, Kenneth K.; Dennis, Barbara H.; Shimakawa, Tomoko; Conlan, Maureen G.; Davis, C. E.; Dale Williams, O.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 13, No. 8, 1993, p. 1205-1212.

Research output: Contribution to journalArticle

Shahar, Eyal ; Folsom, Aaron R. ; Wu, Kenneth K. ; Dennis, Barbara H. ; Shimakawa, Tomoko ; Conlan, Maureen G. ; Davis, C. E. ; Dale Williams, O. / Associations of fish intake and dietary n-3 polyunsaturated fatty acids with a hypocoagulable profile : The atherosclerosis risk in communities (ARIC) study. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 1993 ; Vol. 13, No. 8. pp. 1205-1212.
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