Asthma and IgE antibodies induced by chromium and nickel salts

Harold S. Novey, Michael P Habib, Ian D. Wells

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Metal plating with chromium and nickel has secured an occupational relation with asthma for which an allergic basis has been postulated but not confirmed. A worker who developed de novo asthma after plating with nickel and chromium but not other metals was subjected to inhalational challenge and immunoserologic tests to evaluate this association. He developed acute asthma to chromium sulfate and a biphasic asthma-like response to nickel sulfate. Radioimmunoassays incorporating the challenge materials revealed specific IgE antibodies to the provocative agents but not to another metal, gold, which he could tolerate. The findings support the postulates that bronchial reactivity can be specifically induced by fumes of metallic salts, even in a previously nonallergic individual, and that an IgE type I immunopathogenic mechanism is involved.

Original languageEnglish (US)
Pages (from-to)407-412
Number of pages6
JournalJournal of Allergy and Clinical Immunology
Volume72
Issue number4
DOIs
StatePublished - 1983
Externally publishedYes

Fingerprint

Chromium
Nickel
Immunoglobulin E
Asthma
Salts
Antibodies
Metals
Electroplating
Gold
Radioimmunoassay

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Asthma and IgE antibodies induced by chromium and nickel salts. / Novey, Harold S.; Habib, Michael P; Wells, Ian D.

In: Journal of Allergy and Clinical Immunology, Vol. 72, No. 4, 1983, p. 407-412.

Research output: Contribution to journalArticle

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