Asthma and incident cardiovascular disease: The atherosclerosis risk in communities study

J. G. Schanen, C. Iribarren, Eyal Shahar, N. M. Punjabi, S. S. Rich, P. D. Sorlie, A. R. Folsom

Research output: Contribution to journalArticle

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Abstract

Background: A possible association between asthma and cardiovascular disease has been described in several exploratory studies. Methods: The association of self-reported, doctor diagnosed asthma and incident cardiovascular disease was examined in a biracial cohort of 45-64 year old adults (N = 13501) followed over 14 years. Results: Compared with never having asthma, the multivariate adjusted hazard ratio (HR) of stroke (n = 438) was 1.50 (95% CI 1.04 to 2.15) for a baseline report of ever having asthma (prevalence 5.2%) and 1.55 (95% CI 0.95 to 2.52) for current asthma (prevalence 2.7%). The relative risk of stroke was 1.43 (95% CI 1.03 to 1.98) using a time dependent analysis incorporating follow up reports of asthma. Participants reporting wheeze attacks with shortness of breath also had greater risk for stroke (HR = 1.56, 95% CI 1.18 to 2.06) than participants without these symptoms. The multivariate adjusted relative risk of coronary heart disease (n = 1349) was 0.87 (95% CI 0.66 to 1.14) for ever having asthma, 0.69 (95% CI 0.46 to 1.05) for current asthma at baseline, and 0.88 (95% CI 0.69 to 1.11) using the time dependent analysis. Conclusions: Asthma may be an independent risk factor for incident stroke but not coronary heart disease in middle aged adults. This finding warrants replication and may motivate a search for possible mechanisms that link asthma and stroke.

Original languageEnglish (US)
Pages (from-to)633-638
Number of pages6
JournalThorax
Volume60
Issue number8
DOIs
StatePublished - Aug 2005
Externally publishedYes

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Atherosclerosis
Cardiovascular Diseases
Asthma
Stroke
Coronary Disease
Dyspnea

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Schanen, J. G., Iribarren, C., Shahar, E., Punjabi, N. M., Rich, S. S., Sorlie, P. D., & Folsom, A. R. (2005). Asthma and incident cardiovascular disease: The atherosclerosis risk in communities study. Thorax, 60(8), 633-638. https://doi.org/10.1136/thx.2004.026484

Asthma and incident cardiovascular disease : The atherosclerosis risk in communities study. / Schanen, J. G.; Iribarren, C.; Shahar, Eyal; Punjabi, N. M.; Rich, S. S.; Sorlie, P. D.; Folsom, A. R.

In: Thorax, Vol. 60, No. 8, 08.2005, p. 633-638.

Research output: Contribution to journalArticle

Schanen, JG, Iribarren, C, Shahar, E, Punjabi, NM, Rich, SS, Sorlie, PD & Folsom, AR 2005, 'Asthma and incident cardiovascular disease: The atherosclerosis risk in communities study', Thorax, vol. 60, no. 8, pp. 633-638. https://doi.org/10.1136/thx.2004.026484
Schanen, J. G. ; Iribarren, C. ; Shahar, Eyal ; Punjabi, N. M. ; Rich, S. S. ; Sorlie, P. D. ; Folsom, A. R. / Asthma and incident cardiovascular disease : The atherosclerosis risk in communities study. In: Thorax. 2005 ; Vol. 60, No. 8. pp. 633-638.
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