Asthma as an outcome: Exploring multiple definitions of asthma across birth cohorts in the Environmental influences on Child Health Outcomes Children's Respiratory and Environmental Workgroup

TY - JOUR

T1 - Asthma as an outcome

T2 - Exploring multiple definitions of asthma across birth cohorts in the Environmental influences on Child Health Outcomes Children's Respiratory and Environmental Workgroup

AU - Children's Respiratory and Environmental Workgroup

AU - Visness, Cynthia M.

AU - Gebretsadik, Tebeb

AU - Jackson, Daniel J.

AU - Biagini Myers, Jocelyn

AU - Havstad, Suzanne

AU - Lemanske, Robert F.

AU - Hartert, Tina V.

AU - Khurana Hershey, Gurjit K.

AU - Zoratti, Edward M.

AU - Martin, Lisa J.

AU - Miller, Rachel

AU - Gold, Diane R.

AU - Wright, Anne

AU - Stern, Debra A.

AU - Gern, James E.

AU - Johnson, Christine C.

N1 - Funding Information: The Children's Respiratory and Environmental Workgroup (CREW) is funded by US Department of Health and Human Services/National Institutes of Health grants 5UG3OD023282 and 4UH3OD023282. Additional support was provided by individual cohorts' grants/contracts: Columbia University—P01ES09600, R01 ES008977, P30ES09089, R01 ES013163, and R827027; Tucson Children's Respiratory Study (TCRS)—National Heart, Lung, and Blood Institute 132523; Infant Immune Study (IIS)—HL-56177; Childhood Origins of Asthma Study (COAST)—P01 HL070831, U10 HL064305, and R01 HL061879; Urban Environment and Childhood Asthma Study (URECA)—NO1-AI-25496, NO1-AI-25482, HHSN272200900052C, HHSN272201000052I, National Center for Research Resources/NIH RR00052, M01RR00533, 1UL1RR025771, M01RR00071, 1UL1RR024156, UL1TR001079, 5UL1RR024992-02, and National Center for Advancing Translational Sciences (NCATS)/NIH UL1TR000040; Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS)—R01 ES11170 and R01 ES019890; Epidemiology of Home Allergens and Asthma Study (EHAAS)—R01 AI035786; Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS)—R01 AI050681, R56 AI050681, R01 AI061774, R21 AI059415, K01 AI070606, R21 AI069271, R01 HL113010, R21 ES022321, P01 AI089473, R21 AI080066, R01 AI110450, R01 HD082147, and the Fund for Henry Ford Health System; Childhood Allergy Study (CAS)—R01 AI024156, R03 HL067427, R01 AI051598, Blue Cross Foundation Johnson, and the Fund for Henry Ford Hospital.Disclosure of potential conflict of interest: All authors report grants from the National Institutes of Health (NIH) during the conduct of the study. D. J. Jackson reports grants from GlaxoSmithKline, as well as personal fees from Novartis, Vifor Pharma, Pfizer, Boehringer Ingelheim, and Commense outside the submitted work. R. F. Lemanske reports grants as part of the Clinical and Translational Science Award from NIH, Childhood Origins of Asthma (COAST), and AsthmaNet outside the submitted work; reports personal fees from LSU, the University of Kentucky, and Thermo Fischer outside the submitted work; and reports royalties from Elsevier and UpToDate outside the submitted work. T. V. Hartert reports grants from the World Health Organization outside the submitted work. J. E. Gern reports personal fees from PREP Biopharm, Regeneron, MedImmune, and Ena Pharmaceuticals, as well as personal fees and stock options from Meissa Vaccines outside the submitted work and has a patent for “Methods of propagating rhinovirus C in previously unsusceptible cell lines” issued and a patent for “Adapted rhinovirus C” pending. The rest of the authors declare that they have no relevant conflicts of interest. The Children's Respiratory and Environmental Workgroup (CREW) is funded by US Department of Health and Human Services/ National Institutes of Health grants 5UG3OD023282 and 4UH3OD023282. Additional support was provided by individual cohorts' grants/contracts: Columbia University— P01ES09600, R01 ES008977, P30ES09089, R01 ES013163, and R827027; Tucson Children's Respiratory Study (TCRS)— National Heart, Lung, and Blood Institute 132523; Infant Immune Study (IIS)— HL-56177; Childhood Origins of Asthma Study (COAST)— P01 HL070831, U10 HL064305, and R01 HL061879; Urban Environment and Childhood Asthma Study (URECA)— NO1-AI-25496, NO1-AI-25482, HHSN272200900052C, HHSN272201000052I, National Center for Research Resources/ NIH RR00052, M01RR00533, 1UL1RR025771, M01RR00071, 1UL1RR024156, UL1TR001079, 5UL1RR024992-02, and National Center for Advancing Translational Sciences (NCATS)/ NIH UL1TR000040; Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS)— R01 ES11170 and R01 ES019890; Epidemiology of Home Allergens and Asthma Study (EHAAS)—R01 AI035786; Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS)— R01 AI050681, R56 AI050681, R01 AI061774, R21 AI059415, K01 AI070606, R21 AI069271, R01 HL113010, R21 ES022321, P01 AI089473, R21 AI080066, R01 AI110450, R01 HD082147, and the Fund for Henry Ford Health System; Childhood Allergy Study (CAS)— R01 AI024156, R03 HL067427, R01 AI051598, Blue Cross Foundation Johnson, and the Fund for Henry Ford Hospital. Disclosure of potential conflict of interest: All authors report grants from the National Institutes of Health (NIH) during the conduct of the study. D. J. Jackson reports grants from GlaxoSmithKline, as well as personal fees from Novartis, Vifor Pharma, Pfizer, Boehringer Ingelheim, and Commense outside the submitted work. R. F. Lemanske reports grants as part of the Clinical and Translational Science Award from NIH, Childhood Origins of Asthma (COAST), and AsthmaNet outside the submitted work; reports personal fees from LSU, the University of Kentucky, and Thermo Fischer outside the submitted work; and reports royalties from Elsevier and UpToDate outside the submitted work. T. V. Hartert reports grants from the World Health Organization outside the submitted work. J. E. Gern reports personal fees from PREP Biopharm, Regeneron, MedImmune, and Ena Pharmaceuticals, as well as personal fees and stock options from Meissa Vaccines outside the submitted work and has a patent for “Methods of propagating rhinovirus C in previously unsusceptible cell lines” issued and a patent for “Adapted rhinovirus C” pending. The rest of the authors declare that they have no relevant conflicts of interest. CREW would like to acknowledge the following institutions, investigators, and staff whose efforts contributed to the work presented in this article (principal investigators are indicated by an asterisk):, Columbia Center for Children's Environmental Health (CCCEH): Rachel Miller,* Howard Andrews, Julie Herbstman, Lori Hoepner, Frederica Perera, Matthew Perzanowski, Xinhua Liu, Judyth Ramirez, Janelle Rivera, Deliang Tang, Kylie Wheelock, Jaqueline Jezioro, Tucson Children's Respiratory Study (TCRS): Anne L. Wright,* Fernando D. Martinez,* Wayne Morgan, Debra A. Stern, Dean Billheimer, Brian Hallmark, Paloma Beamer, Nathan Lothrop, Lydia De La Ossa, Silvia Lopez, Marilyn Halonen, Amber Spangenberg, David Spies, Infant Immune Study (IIS): Anne L. Wright,* Fernando D. Martinez,* Wayne Morgan, Debra A. Stern, Dean Billheimer, Brian Hallmark, Paloma Beamer, Nathan Lothrop, Heidi Erickson, Marilyn Halonen, Amber Spangenberg, David Spies, Childhood Origins of Asthma Study (COAST): Robert F. Lemanske, Jr,* Daniel J. Jackson,* James E. Gern, Carole Ober, Ronald E. Gangnon, Michael D. Evans, Victoria Rajamanickam, Christopher Tisler, Lisa Salazar, Susan Doyle, Yury Bochkov, Rebecca Brockman-Schneider, Rose Vrtis, Kristine Grindle, Tressa Pappas, Elizabeth Anderson, Kathy Roberg, Kirsten Carlson-Dakes, Mark DeVries, Douglas DaSilva, Ronald Sorkness, Lance Mikus, Julia Bach, Urban Environment and Childhood Asthma Study (URECA): Johns Hopkins University, Baltimore, Maryland—R. Wood,* E. Matsui, H. Lederman, F. Witter, S. Leimenstoll, D. Scott, M. Cootauco, P. Jones; Boston University School of Medicine, Boston, Massachusetts—G. O'Connor,* W. Cruikshank, M. Sandel, A. Lee-Parritz, C. Jordan, E. Gjerasi, P. Price-Johnson, L. Gagalis, L. Wang, N. Gonzalez, M. Tuzova; Harvard Medical School, Boston, Massachusetts—D. Gold, R. Wright; Columbia University, New York, NY—M. Kattan,* C. Lamm, N. Whitney, P. Yaniv, M. Pierce, J. Jezioro; Mount Sinai School of Medicine, New York, NY—H. Sampson, R. Sperling, N. Rivers; Washington University School of Medicine, St Louis, Missouri: G. Bloomberg,* L. Bacharier,* Y. Sadovsky, E. Tesson, C. Koerkenmeier, R. Sharp, K. Ray, J. Durrange, I. Bauer, A. Freie, V. Morgan; Statistical and Clinical Coordinating Center, Rho, Chapel Hill, NC—C. Visness,* P. Zook, M. Yaeger, J. Martin, A. Calatroni, K. Jaffee, W. Taylor, R. Budrevich, H. Mitchell; Scientific Coordination and Administrative Center, University of Wisconsin, Madison, Wisconsin—W. Busse,* J. Gern,* P. Heinritz, C. Sorkness, K. Hernandez, Y. Bochkov, K. Grindle, A. Dresen, T. Pappas, M. Renneberg, B. Stoffel; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland—P. Gergen, A. Togias, E. Smartt, K. Thompson, Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS): Gurjit K. Khurana Hershey,* Patrick H. Ryan,* Jocelyn M. Biagini Myers,* Grace K. LeMasters,* Kristi Curtsinger, Liza Murrison,* Lisa J. Martin, Jeffrey W. Burkle, Christopher Wolfe, Zachary Flege, David Morgan, Kristina Keidel, Krista Tensing, Taylor Groeschen, The Epidemiology of Home Allergens and Asthma Study (EHAAS): Diane R. Gold, Soma Datta, Sharon O'Toole, Conner Fleurat, Leanna Farnham, Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS): Henry Ford Health System, Detroit, Michigan—C. C. Johnson,* G. Wegienka, S. Havstad, E. Zoratti, A. Cassidy-Bushrow, A. Levin, H. Kim, K. Woodcroft, A. Sitarik, C. Joseph, L. K. Williams, C. Barone, K. Bobbitt, S. Zhang, J. Campbell, K. Bourgeois, M. Aubuchon, J. Ezell, K. Jones; Augusta University, Augusta, Georgia—D. Ownby, Childhood Allergy Study (CAS): D. Ownby,* C. C. Johnson, C. Joseph, E. Zoratti, G. Wegienka, S. Havstad, K. Woodcroft, E. Peterson, S. Hensley Alford, J. McCullough, C. Strauchman Boyer, S. Blocki, G. Birg, N. Akkerman, K. Wells, S. Zhang, C. Nicholas, A. Jones, G. Stouffer The Children's Respiratory and Environmental Workgroup (CREW) is funded by US Department of Health and Human Services/ National Institutes of Health grants 5UG3OD023282 and 4UH3OD023282. Additional support was provided by individual cohorts' grants/contracts: Columbia University— P01ES09600, R01 ES008977, P30ES09089, R01 ES013163, and R827027; Tucson Children's Respiratory Study (TCRS)— National Heart, Lung, and Blood Institute 132523; Infant Immune Study (IIS)— HL-56177; Childhood Origins of Asthma Study (COAST)— P01 HL070831, U10 HL064305, and R01 HL061879; Urban Environment and Childhood Asthma Study (URECA)— NO1-AI-25496, NO1-AI-25482, HHSN272200900052C, HHSN272201000052I, National Center for Research Resources/ NIH RR00052, M01RR00533, 1UL1RR025771, M01RR00071, 1UL1RR024156, UL1TR001079, 5UL1RR024992-02, and National Center for Advancing Translational Sciences (NCATS)/ NIH UL1TR000040; Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS)— R01 ES11170 and R01 ES019890; Epidemiology of Home Allergens and Asthma Study (EHAAS)—R01 AI035786; Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS)— R01 AI050681, R56 AI050681, R01 AI061774, R21 AI059415, K01 AI070606, R21 AI069271, R01 HL113010, R21 ES022321, P01 AI089473, R21 AI080066, R01 AI110450, R01 HD082147, and the Fund for Henry Ford Health System; Childhood Allergy Study (CAS)— R01 AI024156, R03 HL067427, R01 AI051598, Blue Cross Foundation Johnson, and the Fund for Henry Ford Hospital. Disclosure of potential conflict of interest: All authors report grants from the National Institutes of Health (NIH) during the conduct of the study. D. J. Jackson reports grants from GlaxoSmithKline, as well as personal fees from Novartis, Vifor Pharma, Pfizer, Boehringer Ingelheim, and Commense outside the submitted work. R. F. Lemanske reports grants as part of the Clinical and Translational Science Award from NIH, Childhood Origins of Asthma (COAST), and AsthmaNet outside the submitted work; reports personal fees from LSU, the University of Kentucky, and Thermo Fischer outside the submitted work; and reports royalties from Elsevier and UpToDate outside the submitted work. T. V. Hartert reports grants from the World Health Organization outside the submitted work. J. E. Gern reports personal fees from PREP Biopharm, Regeneron, MedImmune, and Ena Pharmaceuticals, as well as personal fees and stock options from Meissa Vaccines outside the submitted work and has a patent for “Methods of propagating rhinovirus C in previously unsusceptible cell lines” issued and a patent for “Adapted rhinovirus C” pending. The rest of the authors declare that they have no relevant conflicts of interest. Funding Information: The Children's Respiratory and Environmental Workgroup (CREW) is funded by US Department of Health and Human Services/National Institutes of Health grants 5UG3OD023282 and 4UH3OD023282. Additional support was provided by individual cohorts' grants/contracts: Columbia University?P01ES09600, R01 ES008977, P30ES09089, R01 ES013163, and R827027; Tucson Children's Respiratory Study (TCRS)?National Heart, Lung, and Blood Institute 132523; Infant Immune Study (IIS)?HL-56177; Childhood Origins of Asthma Study (COAST)?P01 HL070831, U10 HL064305, and R01 HL061879; Urban Environment and Childhood Asthma Study (URECA)?NO1-AI-25496, NO1-AI-25482, HHSN272200900052C, HHSN272201000052I, National Center for Research Resources/NIH RR00052, M01RR00533, 1UL1RR025771, M01RR00071, 1UL1RR024156, UL1TR001079, 5UL1RR024992-02, and National Center for Advancing Translational Sciences (NCATS)/NIH UL1TR000040; Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS)?R01 ES11170 and R01 ES019890; Epidemiology of Home Allergens and Asthma Study (EHAAS)?R01 AI035786; Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS)?R01 AI050681, R56 AI050681, R01 AI061774, R21 AI059415, K01 AI070606, R21 AI069271, R01 HL113010, R21 ES022321, P01 AI089473, R21 AI080066, R01 AI110450, R01 HD082147, and the Fund for Henry Ford Health System; Childhood Allergy Study (CAS)?R01 AI024156, R03 HL067427, R01 AI051598, Blue Cross Foundation Johnson, and the Fund for Henry Ford Hospital.Disclosure of potential conflict of interest: All authors report grants from the National Institutes of Health (NIH) during the conduct of the study. D. J. Jackson reports grants from GlaxoSmithKline, as well as personal fees from Novartis, Vifor Pharma, Pfizer, Boehringer Ingelheim, and Commense outside the submitted work. R. F. Lemanske reports grants as part of the Clinical and Translational Science Award from NIH, Childhood Origins of Asthma (COAST), and AsthmaNet outside the submitted work; reports personal fees from LSU, the University of Kentucky, and Thermo Fischer outside the submitted work; and reports royalties from Elsevier and UpToDate outside the submitted work. T. V. Hartert reports grants from the World Health Organization outside the submitted work. J. E. Gern reports personal fees from PREP Biopharm, Regeneron, MedImmune, and Ena Pharmaceuticals, as well as personal fees and stock options from Meissa Vaccines outside the submitted work and has a patent for ?Methods of propagating rhinovirus C in previously unsusceptible cell lines? issued and a patent for ?Adapted rhinovirus C? pending. The rest of the authors declare that they have no relevant conflicts of interest. CREW would like to acknowledge the following institutions, investigators, and staff whose efforts contributed to the work presented in this article (principal investigators are indicated by an asterisk):, Columbia Center for Children's Environmental Health (CCCEH): Rachel Miller,* Howard Andrews, Julie Herbstman, Lori Hoepner, Frederica Perera, Matthew Perzanowski, Xinhua Liu, Judyth Ramirez, Janelle Rivera, Deliang Tang, Kylie Wheelock, Jaqueline Jezioro, Tucson Children's Respiratory Study (TCRS): Anne L. Wright,* Fernando D. Martinez,* Wayne Morgan, Debra A. Stern, Dean Billheimer, Brian Hallmark, Paloma Beamer, Nathan Lothrop, Lydia De La Ossa, Silvia Lopez, Marilyn Halonen, Amber Spangenberg, David Spies, Infant Immune Study (IIS): Anne L. Wright,* Fernando D. Martinez,* Wayne Morgan, Debra A. Stern, Dean Billheimer, Brian Hallmark, Paloma Beamer, Nathan Lothrop, Heidi Erickson, Marilyn Halonen, Amber Spangenberg, David Spies, Childhood Origins of Asthma Study (COAST): Robert F. Lemanske, Jr,* Daniel J. Jackson,* James E. Gern, Carole Ober, Ronald E. Gangnon, Michael D. Evans, Victoria Rajamanickam, Christopher Tisler, Lisa Salazar, Susan Doyle, Yury Bochkov, Rebecca Brockman-Schneider, Rose Vrtis, Kristine Grindle, Tressa Pappas, Elizabeth Anderson, Kathy Roberg, Kirsten Carlson-Dakes, Mark DeVries, Douglas DaSilva, Ronald Sorkness, Lance Mikus, Julia Bach, Urban Environment and Childhood Asthma Study (URECA): Johns Hopkins University, Baltimore, Maryland?R. Wood,* E. Matsui, H. Lederman, F. Witter, S. Leimenstoll, D. Scott, M. Cootauco, P. Jones; Boston University School of Medicine, Boston, Massachusetts?G. O'Connor,* W. Cruikshank, M. Sandel, A. Lee-Parritz, C. Jordan, E. Gjerasi, P. Price-Johnson, L. Gagalis, L. Wang, N. Gonzalez, M. Tuzova; Harvard Medical School, Boston, Massachusetts?D. Gold, R. Wright; Columbia University, New York, NY?M. Kattan,* C. Lamm, N. Whitney, P. Yaniv, M. Pierce, J. Jezioro; Mount Sinai School of Medicine, New York, NY?H. Sampson, R. Sperling, N. Rivers; Washington University School of Medicine, St Louis, Missouri: G. Bloomberg,* L. Bacharier,* Y. Sadovsky, E. Tesson, C. Koerkenmeier, R. Sharp, K. Ray, J. Durrange, I. Bauer, A. Freie, V. Morgan; Statistical and Clinical Coordinating Center, Rho, Chapel Hill, NC?C. Visness,* P. Zook, M. Yaeger, J. Martin, A. Calatroni, K. Jaffee, W. Taylor, R. Budrevich, H. Mitchell; Scientific Coordination and Administrative Center, University of Wisconsin, Madison, Wisconsin?W. Busse,* J. Gern,* P. Heinritz, C. Sorkness, K. Hernandez, Y. Bochkov, K. Grindle, A. Dresen, T. Pappas, M. Renneberg, B. Stoffel; National Institute of Allergy and Infectious Diseases, Bethesda, Maryland?P. Gergen, A. Togias, E. Smartt, K. Thompson, Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS): Gurjit K. Khurana Hershey,* Patrick H. Ryan,* Jocelyn M. Biagini Myers,* Grace K. LeMasters,* Kristi Curtsinger, Liza Murrison,* Lisa J. Martin, Jeffrey W. Burkle, Christopher Wolfe, Zachary Flege, David Morgan, Kristina Keidel, Krista Tensing, Taylor Groeschen, The Epidemiology of Home Allergens and Asthma Study (EHAAS): Diane R. Gold, Soma Datta, Sharon O'Toole, Conner Fleurat, Leanna Farnham, Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS): Henry Ford Health System, Detroit, Michigan?C. C. Johnson,* G. Wegienka, S. Havstad, E. Zoratti, A. Cassidy-Bushrow, A. Levin, H. Kim, K. Woodcroft, A. Sitarik, C. Joseph, L. K. Williams, C. Barone, K. Bobbitt, S. Zhang, J. Campbell, K. Bourgeois, M. Aubuchon, J. Ezell, K. Jones; Augusta University, Augusta, Georgia?D. Ownby, Childhood Allergy Study (CAS): D. Ownby,* C. C. Johnson, C. Joseph, E. Zoratti, G. Wegienka, S. Havstad, K. Woodcroft, E. Peterson, S. Hensley Alford, J. McCullough, C. Strauchman Boyer, S. Blocki, G. Birg, N. Akkerman, K. Wells, S. Zhang, C. Nicholas, A. Jones, G. Stouffer

PY - 2019/9

Y1 - 2019/9

UR - http://www.scopus.com/inward/record.url?scp=85068003799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068003799&partnerID=8YFLogxK

U2 - 10.1016/j.jaci.2019.05.025

DO - 10.1016/j.jaci.2019.05.025

M3 - Article

C2 - 31163174

AN - SCOPUS:85068003799

VL - 144

SP - 866-869.e4

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 3

ER -