Asthma pharmacogenetics and the development of genetic profiles for personalized medicine

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Human genetics research will be critical to the development of genetic profiles for personalized or precision medicine in asthma. Genetic profiles will consist of gene variants that predict individual disease susceptibility and risk for progression, predict which pharmaco-logic therapies will result in a maximal therapeutic benefit, and predict whether a therapy will result in an adverse response and should be avoided in a given individual. Pharmacogenetic studies of the glucocorticoid, leukotriene, and β2-adrenergic receptor pathways have focused on candidate genes within these pathways and, in addition to a small number of genome-wide association studies, have identifed genetic loci associated with therapeutic responsiveness. This review summarizes these pharmacogenetic discoveries and the future of genetic profiles for personalized medicine in asthma. The benefit of a personalized, tailored approach to health care delivery is needed in the development of expensive biologic drugs directed at a specific biologic pathway. Prior pharmacogenetic discoveries, in combination with additional variants identified in future studies, will form the basis for future genetic profiles for personalized tailored approaches to maximize therapeutic benefit for an individual asthmatic while minimizing the risk for adverse events.

Original languageEnglish (US)
Pages (from-to)9-22
Number of pages14
JournalPharmacogenomics and Personalized Medicine
Volume8
DOIs
StatePublished - Jan 16 2015
Externally publishedYes

Keywords

  • Asthma
  • Genome-wide association study
  • Pharmacogenetics
  • Response heterogeneity
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Fingerprint

Dive into the research topics of 'Asthma pharmacogenetics and the development of genetic profiles for personalized medicine'. Together they form a unique fingerprint.

Cite this