Asymmetric synthesis of topographically constrained amino acids: synthesis of the optically pure isomers of α,β-dimethyl-phenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Wieslaw M. Kazmierski, Victor J Hruby

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

All four isomers of α,β-dimethylphenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid have been synthesized in high optical purity for use in the design of topographically constrained peptides.

Original languageEnglish (US)
Pages (from-to)5769-5772
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number41
DOIs
Publication statusPublished - Oct 7 1991

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ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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