Asymmetric synthesis of topographically constrained amino acids: synthesis of the optically pure isomers of α,β-dimethyl-phenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Wieslaw M. Kazmierski, Victor J Hruby

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

All four isomers of α,β-dimethylphenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid have been synthesized in high optical purity for use in the design of topographically constrained peptides.

Original languageEnglish (US)
Pages (from-to)5769-5772
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number41
DOIs
StatePublished - Oct 7 1991

Fingerprint

Phenylalanine
Isomers
Amino Acids
Peptides
1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

@article{727f25e393fd498ca7a4a0c69f8644f9,
title = "Asymmetric synthesis of topographically constrained amino acids: synthesis of the optically pure isomers of α,β-dimethyl-phenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid",
abstract = "All four isomers of α,β-dimethylphenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid have been synthesized in high optical purity for use in the design of topographically constrained peptides.",
author = "Kazmierski, {Wieslaw M.} and Hruby, {Victor J}",
year = "1991",
month = "10",
day = "7",
doi = "10.1016/S0040-4039(00)93551-2",
language = "English (US)",
volume = "32",
pages = "5769--5772",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "41",

}

TY - JOUR

T1 - Asymmetric synthesis of topographically constrained amino acids

T2 - synthesis of the optically pure isomers of α,β-dimethyl-phenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

AU - Kazmierski, Wieslaw M.

AU - Hruby, Victor J

PY - 1991/10/7

Y1 - 1991/10/7

N2 - All four isomers of α,β-dimethylphenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid have been synthesized in high optical purity for use in the design of topographically constrained peptides.

AB - All four isomers of α,β-dimethylphenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid have been synthesized in high optical purity for use in the design of topographically constrained peptides.

UR - http://www.scopus.com/inward/record.url?scp=0025993024&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025993024&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)93551-2

DO - 10.1016/S0040-4039(00)93551-2

M3 - Article

AN - SCOPUS:0025993024

VL - 32

SP - 5769

EP - 5772

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 41

ER -