Asymmetric synthesis of unusual amino acid: Synthesis of four isomers of β-methyl-3-(2'-naphthyl)alanine

Wei Yuan, Victor J Hruby

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The synthesis of all four individual isomers of 3-methyl-3-(2'-naphthyl)analine was accomplished using asymmetric conjugate 1,4-addition followed by direct or indirect azidation using an Evans-type chiral auxiliary (4-phenyl-2-oxazolidinone).

Original languageEnglish (US)
Pages (from-to)3853-3856
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number22
DOIs
StatePublished - Jun 2 1997

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Oxazolidinones
Isomers
Amino Acids
3-(2-naphthyl)alanine

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Asymmetric synthesis of unusual amino acid : Synthesis of four isomers of β-methyl-3-(2'-naphthyl)alanine. / Yuan, Wei; Hruby, Victor J.

In: Tetrahedron Letters, Vol. 38, No. 22, 02.06.1997, p. 3853-3856.

Research output: Contribution to journalArticle

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