Atenolol for ventricular ectopy: A dose-response study

Paul E. Fenster, Dwight Reynolds, Lawrence D. Horwitz, Douglass Morrison, Steven Goldman, Udho Thadani, Ralph Lazzara, Ruth Serokman, Frank I. Marcus

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The antiarrhythmic efficacy, safety, and tolerance of atenolol was evaluated in 32 patients with an average of at least 60 ventricular ectopic depolarizations/hr. Patients received, single-blind, the following treatments for 2 weeks each: placebo and atenolol, 50, 100, and 200 mg daily. A 24-hour ambulatory ECG recording was obtained each week. Reduction in ventricular ectopic frequency by at least 75% occurred in six of 32 patients receiving 50 mg daily, five of 30 patients receiving 100 mg daily, and three of 21 patients receiving 200 mg daily (P = not significant for any paired dose comparison). No patient who failed to respond to a lower dose responded to 200 mg daily. The frequency of ventricular tachycardia was reduced by at least 75% in eight of 17 patients receiving 50 mg daily, seven of 16 patients receiving 100 mg daily, and eight of 11 receiving 200 mg daily (P = not significant for any paired dose comparison). Atenolol was discontinued because of adverse effects in 12 patients. The results indicate that atenolol is more effective in suppressing ventricular tachycardia than in suppressing overall ventricular ectopy.

Original languageEnglish (US)
Pages (from-to)118-123
Number of pages6
JournalClinical Pharmacology and Therapeutics
Volume41
Issue number1
DOIs
StatePublished - Jan 1987
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Atenolol for ventricular ectopy: A dose-response study'. Together they form a unique fingerprint.

  • Cite this

    Fenster, P. E., Reynolds, D., Horwitz, L. D., Morrison, D., Goldman, S., Thadani, U., Lazzara, R., Serokman, R., & Marcus, F. I. (1987). Atenolol for ventricular ectopy: A dose-response study. Clinical Pharmacology and Therapeutics, 41(1), 118-123. https://doi.org/10.1038/clpt.1987.20