Atherosclerosis and cancer: Flip sides of the neoplastic response in mammalian cells?

Kenneth S. Ramos, Charles R. Partridge

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Scientific and medical evidence over the past 30 years has established striking parallels between atherosclerosis and cancer - pathogenetic relationships that cross the boundaries of fiction into the realm of reason. Both diseases in humans are characterized by uncontrolled regulation of cellular growth and differentiation and share many common genomic targets during the course of growth dysregulation. Such parallels can be reconciled if atherosclerotic plaques are viewed as neoplasms of smooth muscle origin.

Original languageEnglish (US)
Pages (from-to)245-255
Number of pages11
JournalCardiovascular toxicology
Volume5
Issue number3
DOIs
StatePublished - Sep 1 2005
Externally publishedYes

Keywords

  • Atherosclerosis
  • Cancer
  • Chemical carcinogens
  • Environmental disease
  • Neoplasia

ASJC Scopus subject areas

  • Molecular Biology
  • Toxicology
  • Cardiology and Cardiovascular Medicine

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