Atomic resolution of cytoskeletal protein by scanning tunneling microscopy

Stuart R. Hameroff, Lawrence A. Vernetti, Y. C. Lee, Dror Sarid, Richard C. Watt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Preparation and scanning tunneling microscopy (STM) imaging of cytokeratin cytoskeletal protein are reported. Results show structures 45 nm in length, diameter 1.8 nm, with helical periodicity of 0.54 nm and a helical rise of 100 degrees. Atomic resolution as well as primary (individual amino acids), secondary (alpha helix), tertiary (dimer), and quaternary (tetramer) levels of protein structure are demonstrated. It is argued that STM may be used to modify, manipulate, and/or construct biomolecules and molecular devices.

Original languageEnglish (US)
Title of host publicationBiomedical Engineering Perspectives
Subtitle of host publicationHealth Care Technologies for the 1990's and Beyond
PublisherPubl by IEEE
Pages1724
Number of pages1
Editionpt 4
ISBN (Print)0879425598
StatePublished - 1990
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 4
ISSN (Print)0589-1019

Other

OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA
Period11/1/9011/4/90

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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