Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma

Theresa W. Guilbert, Wayne J Morgan, Robert S. Zeiger, Leonard B. Bacharier, Susan J. Boehmer, Marzena Krawiec, Gary Larsen, Robert F. Lemanske, Andrew Liu, David T. Mauger, Chris Sorkness, Stanley J. Szefler, Robert C. Strunk, Lynn M. Taussig, Fernando Martinez

Research output: Contribution to journalArticle

274 Citations (Scopus)

Abstract

Few studies have characterized the atopic profile of toddler-aged children with recurrent wheezing at high risk of the development of persistent asthma. We sought to determine the atopic profile of toddler-aged children with frequent wheeze at high risk for the development of persistent asthma who either had a parental history of asthma, a personal history of atopic dermatitis, or both. Participants enrolled in the Prevention of Early Asthma in Kids study (n = 285) on the basis of a modified Asthma Predictive Index were characterized on the basis of allergy and asthma questionnaire responses and allergy skin puncture test results. The majority of the children (60.7%, n = 148) were sensitized to either food or aeroallergens. Male children were significantly more likely to be sensitized to aeroallergens (P =. 03) and to have a blood eosinophil level of 4% or greater (P =. 03) and a total serum IgE level of greater than 100 IU/mL (P =. 0004). Additionally, eosinophilia and total serum IgE level had the strongest correlation with aeroallergen sensitization. The high prevalence of aeroallergen sensitization in this high-risk cohort suggests that aeroallergens might have an important role in the early development of asthma. As such, the Prevention of Early Asthma in Kids cohort appears to be an appropriate cohort in which to test whether early intervention with an inhaled corticosteroid can significantly attenuate, or perhaps even prevent, the allergic march from the initial stages of allergic sensitization to the subsequent development of asthma in toddlers with episodic wheezing.

Original languageEnglish (US)
Pages (from-to)1282-1287
Number of pages6
JournalJournal of Allergy and Clinical Immunology
Volume114
Issue number6
DOIs
StatePublished - Dec 2004

Fingerprint

Respiratory Sounds
Asthma
Immunoglobulin E
Hypersensitivity
Eosinophilia
Atopic Dermatitis
Skin Tests
Serum
Punctures
Eosinophils
Adrenal Cortex Hormones
Food

Keywords

  • aeroallergen and food sensitization
  • Allergens
  • asthma predictive index
  • atopy
  • clinical trials
  • early childhood asthma
  • fluticasone
  • glucocorticoids
  • intermittent wheezing
  • prevention of asthma
  • research network
  • skin prick test

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. / Guilbert, Theresa W.; Morgan, Wayne J; Zeiger, Robert S.; Bacharier, Leonard B.; Boehmer, Susan J.; Krawiec, Marzena; Larsen, Gary; Lemanske, Robert F.; Liu, Andrew; Mauger, David T.; Sorkness, Chris; Szefler, Stanley J.; Strunk, Robert C.; Taussig, Lynn M.; Martinez, Fernando.

In: Journal of Allergy and Clinical Immunology, Vol. 114, No. 6, 12.2004, p. 1282-1287.

Research output: Contribution to journalArticle

Guilbert, TW, Morgan, WJ, Zeiger, RS, Bacharier, LB, Boehmer, SJ, Krawiec, M, Larsen, G, Lemanske, RF, Liu, A, Mauger, DT, Sorkness, C, Szefler, SJ, Strunk, RC, Taussig, LM & Martinez, F 2004, 'Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma', Journal of Allergy and Clinical Immunology, vol. 114, no. 6, pp. 1282-1287. https://doi.org/10.1016/j.jaci.2004.09.020
Guilbert, Theresa W. ; Morgan, Wayne J ; Zeiger, Robert S. ; Bacharier, Leonard B. ; Boehmer, Susan J. ; Krawiec, Marzena ; Larsen, Gary ; Lemanske, Robert F. ; Liu, Andrew ; Mauger, David T. ; Sorkness, Chris ; Szefler, Stanley J. ; Strunk, Robert C. ; Taussig, Lynn M. ; Martinez, Fernando. / Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. In: Journal of Allergy and Clinical Immunology. 2004 ; Vol. 114, No. 6. pp. 1282-1287.
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abstract = "Few studies have characterized the atopic profile of toddler-aged children with recurrent wheezing at high risk of the development of persistent asthma. We sought to determine the atopic profile of toddler-aged children with frequent wheeze at high risk for the development of persistent asthma who either had a parental history of asthma, a personal history of atopic dermatitis, or both. Participants enrolled in the Prevention of Early Asthma in Kids study (n = 285) on the basis of a modified Asthma Predictive Index were characterized on the basis of allergy and asthma questionnaire responses and allergy skin puncture test results. The majority of the children (60.7{\%}, n = 148) were sensitized to either food or aeroallergens. Male children were significantly more likely to be sensitized to aeroallergens (P =. 03) and to have a blood eosinophil level of 4{\%} or greater (P =. 03) and a total serum IgE level of greater than 100 IU/mL (P =. 0004). Additionally, eosinophilia and total serum IgE level had the strongest correlation with aeroallergen sensitization. The high prevalence of aeroallergen sensitization in this high-risk cohort suggests that aeroallergens might have an important role in the early development of asthma. As such, the Prevention of Early Asthma in Kids cohort appears to be an appropriate cohort in which to test whether early intervention with an inhaled corticosteroid can significantly attenuate, or perhaps even prevent, the allergic march from the initial stages of allergic sensitization to the subsequent development of asthma in toddlers with episodic wheezing.",
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