ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance

Yingying Pu, Yingxing Li, Xin Jin, Tian Tian, Qi Ma, Ziyi Zhao, Ssu yuan Lin, Zhanghua Chen, Binghui Li, Guang Yao, Mark C. Leake, Chien Jung Lo, Fan Bai

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

In this work, Pu et al. introduced a concept of “dormancy depth” that provides a unifying framework for understanding both persisters and viable but non-culturable cells. Subsequent mechanistic investigations revealed how ATP-dependent dynamic protein aggregation regulates cellular dormancy and resuscitation, the fine control of which facilitates bacterial drug tolerance.

Original languageEnglish (US)
Pages (from-to)143-156.e4
JournalMolecular cell
Volume73
Issue number1
DOIs
StatePublished - Jan 3 2019

Keywords

  • ATP
  • DnaK-ClpB complex
  • bacterial antibiotic tolerance
  • cell resuscitation
  • dormancy depth
  • persisters
  • protein aggregates
  • viable but non-culturable cells

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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