ATPases and lens ion balance

Christopher A. Paterson, Nicholas A Delamere

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In the lens, different cells appear to be specialized such that some have a high capacity for energy-dependent ion transport while others do not. This short review describes the distribution of functional Na,K-ATPase activity and Ca-ATPase activity in the lens. Movement of ions in the extracellular space between lens fibers, a topic studied by David Maurice 25 years ago, is discussed together with cell-to-cell movement of ions which is facilitated by extensive coupling in the lens cell mass. The expression of different Na,K-ATPase and Ca-ATPase isoforms in lens epithelium and fiber cells is considered along with mechanisms that potentially regulate the activity of these transport proteins.

Original languageEnglish (US)
Pages (from-to)699-703
Number of pages5
JournalExperimental Eye Research
Volume78
Issue number3
DOIs
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Lenses
Adenosine Triphosphatases
Ions
Ion Transport
Extracellular Space
Cell Movement
Carrier Proteins
Protein Isoforms
Epithelium

Keywords

  • Ca-ATPase
  • Lens
  • Na,K-ATPase
  • PMCA
  • SERCA

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

ATPases and lens ion balance. / Paterson, Christopher A.; Delamere, Nicholas A.

In: Experimental Eye Research, Vol. 78, No. 3, 03.2004, p. 699-703.

Research output: Contribution to journalArticle

Paterson, Christopher A. ; Delamere, Nicholas A. / ATPases and lens ion balance. In: Experimental Eye Research. 2004 ; Vol. 78, No. 3. pp. 699-703.
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