Attachment & detachment of prostate cancer cells in a microfluidic system

L. S.L. Cheung, X. J. Zheng, A. Stopa, J. Schroeder, R. L. Hemark, J. C. Baygents, R. Guzman, Y. Zohar

Research output: Contribution to conferencePaper

1 Scopus citations

Abstract

Cadherins make up a family of cell adhesion molecules, and one cadherin subtype only interacts with its counter receptor. Cancer cells typically down-regulate Ecadherin and up-regulate N-cadherin. Hence, a microchannel-based system is developed, with immobilized anti-N-cadherin antibodies, for highly specific capture of prostate cancer cells under both static (no-flow) and dynamic (flow) conditions. The maximum number of detached cells, after capture, is found to depend not only on the flow-induced shear stress but also on the rate of change of the applied shear stress.

Original languageEnglish (US)
Pages1159-1161
Number of pages3
StatePublished - Jan 1 2008
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
Duration: Oct 12 2008Oct 16 2008

Other

Other12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
CountryUnited States
CitySan Diego, CA
Period10/12/0810/16/08

Keywords

  • Cell attachment/detachment
  • Circulating tumor cell
  • Microdevices

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Cheung, L. S. L., Zheng, X. J., Stopa, A., Schroeder, J., Hemark, R. L., Baygents, J. C., Guzman, R., & Zohar, Y. (2008). Attachment & detachment of prostate cancer cells in a microfluidic system. 1159-1161. Paper presented at 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008, San Diego, CA, United States.