Attachment & detachment of prostate cancer cells in a microfluidic system

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Cadherins make up a family of cell adhesion molecules, and one cadherin subtype only interacts with its counter receptor. Cancer cells typically down-regulate Ecadherin and up-regulate N-cadherin. Hence, a microchannel-based system is developed, with immobilized anti-N-cadherin antibodies, for highly specific capture of prostate cancer cells under both static (no-flow) and dynamic (flow) conditions. The maximum number of detached cells, after capture, is found to depend not only on the flow-induced shear stress but also on the rate of change of the applied shear stress.

Original languageEnglish (US)
Title of host publication12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference
PublisherChemical and Biological Microsystems Society
Pages1159-1161
Number of pages3
StatePublished - 2008
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
Duration: Oct 12 2008Oct 16 2008

Other

Other12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
CountryUnited States
CitySan Diego, CA
Period10/12/0810/16/08

Fingerprint

Cadherins
Microfluidics
Shear stress
Cells
Cell adhesion
Microchannels
Antibodies
Molecules
Cell Adhesion Molecules

Keywords

  • Cell attachment/detachment
  • Circulating tumor cell
  • Microdevices

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Cheung, L. S. L., Zheng, X. J., Stopa, A., Schroeder, J., Heimark, R. L., Baygents, J. C., ... Zohar, Y. (2008). Attachment & detachment of prostate cancer cells in a microfluidic system. In 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference (pp. 1159-1161). Chemical and Biological Microsystems Society.

Attachment & detachment of prostate cancer cells in a microfluidic system. / Cheung, L. S L; Zheng, X. J.; Stopa, A.; Schroeder, Joyce; Heimark, Ronald L; Baygents, James C; Guzman, Roberto Z; Zohar, Yitshak.

12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference. Chemical and Biological Microsystems Society, 2008. p. 1159-1161.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cheung, LSL, Zheng, XJ, Stopa, A, Schroeder, J, Heimark, RL, Baygents, JC, Guzman, RZ & Zohar, Y 2008, Attachment & detachment of prostate cancer cells in a microfluidic system. in 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference. Chemical and Biological Microsystems Society, pp. 1159-1161, 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008, San Diego, CA, United States, 10/12/08.
Cheung LSL, Zheng XJ, Stopa A, Schroeder J, Heimark RL, Baygents JC et al. Attachment & detachment of prostate cancer cells in a microfluidic system. In 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference. Chemical and Biological Microsystems Society. 2008. p. 1159-1161
Cheung, L. S L ; Zheng, X. J. ; Stopa, A. ; Schroeder, Joyce ; Heimark, Ronald L ; Baygents, James C ; Guzman, Roberto Z ; Zohar, Yitshak. / Attachment & detachment of prostate cancer cells in a microfluidic system. 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference. Chemical and Biological Microsystems Society, 2008. pp. 1159-1161
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