Attenuated Late-Phase Arc Transcription in the Dentate Gyrus of Mice Lacking Egr3

Amanda Maple, Rachel E. Lackie, Diana I. Elizalde, Stephanie L. Grella, Chelsey C. Damphousse, Collin Xa, Amelia L. Gallitano, Diano F. Marrone

Research output: Research - peer-reviewArticle

Abstract

The dentate gyrus (DG) engages in sustained Arc transcription for at least 8 hours following behavioral induction, and this time course may be functionally coupled to the unique role of the DG in hippocampus-dependent learning and memory. The factors that regulate long-term DG Arc expression, however, remain poorly understood. Animals lacking Egr3 show less Arc expression following convulsive stimulation, but the effect of Egr3 ablation on behaviorally induced Arc remains unknown. To address this, Egr3-/- and wild-type (WT) mice explored novel spatial environments and were sacrificed either immediately or after 5, 60, 240, or 480 minutes, and Arc expression was quantified by fluorescence in situ hybridization. Although short-term (i.e., within 60 min) Arc expression was equivalent across genotypes, DG Arc expression was selectively reduced at 240 and 480 minutes in mice lacking Egr3. These data demonstrate the involvement of Egr3 in regulating the late protein-dependent phase of Arc expression in the DG.

LanguageEnglish (US)
Article number6063048
JournalNeural Plasticity
Volume2017
DOIs
StatePublished - 2017

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Dentate Gyrus
Parahippocampal Gyrus
Fluorescence In Situ Hybridization
Genotype
Learning
Proteins

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Maple, A., Lackie, R. E., Elizalde, D. I., Grella, S. L., Damphousse, C. C., Xa, C., ... Marrone, D. F. (2017). Attenuated Late-Phase Arc Transcription in the Dentate Gyrus of Mice Lacking Egr3. Neural Plasticity, 2017, [6063048]. DOI: 10.1155/2017/6063048

Attenuated Late-Phase Arc Transcription in the Dentate Gyrus of Mice Lacking Egr3. / Maple, Amanda; Lackie, Rachel E.; Elizalde, Diana I.; Grella, Stephanie L.; Damphousse, Chelsey C.; Xa, Collin; Gallitano, Amelia L.; Marrone, Diano F.

In: Neural Plasticity, Vol. 2017, 6063048, 2017.

Research output: Research - peer-reviewArticle

Maple, A, Lackie, RE, Elizalde, DI, Grella, SL, Damphousse, CC, Xa, C, Gallitano, AL & Marrone, DF 2017, 'Attenuated Late-Phase Arc Transcription in the Dentate Gyrus of Mice Lacking Egr3' Neural Plasticity, vol 2017, 6063048. DOI: 10.1155/2017/6063048
Maple A, Lackie RE, Elizalde DI, Grella SL, Damphousse CC, Xa C et al. Attenuated Late-Phase Arc Transcription in the Dentate Gyrus of Mice Lacking Egr3. Neural Plasticity. 2017;2017. 6063048. Available from, DOI: 10.1155/2017/6063048
Maple, Amanda ; Lackie, Rachel E. ; Elizalde, Diana I. ; Grella, Stephanie L. ; Damphousse, Chelsey C. ; Xa, Collin ; Gallitano, Amelia L. ; Marrone, Diano F./ Attenuated Late-Phase Arc Transcription in the Dentate Gyrus of Mice Lacking Egr3. In: Neural Plasticity. 2017 ; Vol. 2017.
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