Attenuated long-term Arc expression in the aged fascia dentata

Diano F. Marrone, Elham Satvat, Michael J. Shaner, Paul F. Worley, Carol A. Barnes

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

One prominent component of aging is a defect in memory stabilization. To understand how the formation of enduring memories is altered in the aged brain, long-term markers of the biological events that may mediate memory consolidation were used to examine the activity dynamics of hippocampal circuits over extended intervals. The immediate early gene Arc, which is implicated in both durable memory and synaptic plasticity, is expressed in the fascia dentata (FD) for long periods following behavioral experience. To test the hypothesis that aging alters long-term Arc transcription in the FD, a region critical for spatial memory and impaired with progressive age, young and aged rats explored a novel environment twice, separated by an 8-hour interval, and FD Arc transcription was assessed. Relative to young rats, (a) fewer granule cells in the aged FD transcribe arc 8 hours after spatial exploration, and (b) this decrease is correlated with impaired spatial memory. These findings are consistent with behavioral evidence of age-related decline in hippocampal-dependent memory processing long after an event is to be remembered, and reaffirm the integral role of the FD in the neural circuits supporting durable memory.

Original languageEnglish (US)
Pages (from-to)979-990
Number of pages12
JournalNeurobiology of Aging
Volume33
Issue number5
DOIs
StatePublished - May 1 2012

Keywords

  • Arg3.1
  • Consolidation
  • Dentate gyrus
  • Granule cell
  • Immediate-early genes (IEG)
  • Long-term memory

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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