Autoimmune hepatitis in African Americans: Presenting features and response to therapy

Kie N. Lim, Roberto L. Casanova, Thomas D Boyer, Christine Janes Bruno

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

OBJECTIVES: African Americans are at an increased risk for certain diseases and more frequently suffer complications of those diseases relative to their white counterparts. Most studies of autoimmune hepatitis consist of entirely white populations. The Emory University system of hospitals serves a large African American population, including a significant number of African Americans with autoimmune hepatitis. The goal of this study was to determine if the presentation and response to therapy in African Americans is, like other diseases, different than in whites. METHODS: This is a retrospective study from a tertiary referral center that examines the initial presenting features and response to therapy of African Americans (n = 27) and whites (n = 24) with autoimmune hepatitis. RESULTS: Eighty-five percent of African Americans had cirrhosis on the initial liver biopsy, as compared with 38% of whites. Although not statistically significant, the African Americans presented at an earlier age than white patients. The disease also appeared more advanced in African Americans, as bilibubin levels tended to be higher, but not significantly, and PTs were more prolonged. Both groups responded well to therapy, with significant falls in serum levels of AST, ALT, and bilirubin. Fifty percent of African Americans and 48% of whites entered a biochemical remission. The amount of prednisone required to maintain remission at follow-up was greater in African Americans. CONCLUSION: In contrast to whites, the majority of African Americans present with cirrhosis. Despite the high prevalence of cirrhosis, the response to therapy is good. However, more immunosuppression is required to control the disease in African Americans.

Original languageEnglish (US)
Pages (from-to)3390-3394
Number of pages5
JournalAmerican Journal of Gastroenterology
Volume96
Issue number12
DOIs
StatePublished - 2001

Fingerprint

Autoimmune Hepatitis
African Americans
Therapeutics
Fibrosis
Prednisone
Bilirubin
Tertiary Care Centers
Immunosuppression
Population
Retrospective Studies

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Autoimmune hepatitis in African Americans : Presenting features and response to therapy. / Lim, Kie N.; Casanova, Roberto L.; Boyer, Thomas D; Bruno, Christine Janes.

In: American Journal of Gastroenterology, Vol. 96, No. 12, 2001, p. 3390-3394.

Research output: Contribution to journalArticle

Lim, Kie N. ; Casanova, Roberto L. ; Boyer, Thomas D ; Bruno, Christine Janes. / Autoimmune hepatitis in African Americans : Presenting features and response to therapy. In: American Journal of Gastroenterology. 2001 ; Vol. 96, No. 12. pp. 3390-3394.
@article{393142c38ae64eb7a96a0e328816f402,
title = "Autoimmune hepatitis in African Americans: Presenting features and response to therapy",
abstract = "OBJECTIVES: African Americans are at an increased risk for certain diseases and more frequently suffer complications of those diseases relative to their white counterparts. Most studies of autoimmune hepatitis consist of entirely white populations. The Emory University system of hospitals serves a large African American population, including a significant number of African Americans with autoimmune hepatitis. The goal of this study was to determine if the presentation and response to therapy in African Americans is, like other diseases, different than in whites. METHODS: This is a retrospective study from a tertiary referral center that examines the initial presenting features and response to therapy of African Americans (n = 27) and whites (n = 24) with autoimmune hepatitis. RESULTS: Eighty-five percent of African Americans had cirrhosis on the initial liver biopsy, as compared with 38{\%} of whites. Although not statistically significant, the African Americans presented at an earlier age than white patients. The disease also appeared more advanced in African Americans, as bilibubin levels tended to be higher, but not significantly, and PTs were more prolonged. Both groups responded well to therapy, with significant falls in serum levels of AST, ALT, and bilirubin. Fifty percent of African Americans and 48{\%} of whites entered a biochemical remission. The amount of prednisone required to maintain remission at follow-up was greater in African Americans. CONCLUSION: In contrast to whites, the majority of African Americans present with cirrhosis. Despite the high prevalence of cirrhosis, the response to therapy is good. However, more immunosuppression is required to control the disease in African Americans.",
author = "Lim, {Kie N.} and Casanova, {Roberto L.} and Boyer, {Thomas D} and Bruno, {Christine Janes}",
year = "2001",
doi = "10.1016/S0002-9270(01)03834-5",
language = "English (US)",
volume = "96",
pages = "3390--3394",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "12",

}

TY - JOUR

T1 - Autoimmune hepatitis in African Americans

T2 - Presenting features and response to therapy

AU - Lim, Kie N.

AU - Casanova, Roberto L.

AU - Boyer, Thomas D

AU - Bruno, Christine Janes

PY - 2001

Y1 - 2001

N2 - OBJECTIVES: African Americans are at an increased risk for certain diseases and more frequently suffer complications of those diseases relative to their white counterparts. Most studies of autoimmune hepatitis consist of entirely white populations. The Emory University system of hospitals serves a large African American population, including a significant number of African Americans with autoimmune hepatitis. The goal of this study was to determine if the presentation and response to therapy in African Americans is, like other diseases, different than in whites. METHODS: This is a retrospective study from a tertiary referral center that examines the initial presenting features and response to therapy of African Americans (n = 27) and whites (n = 24) with autoimmune hepatitis. RESULTS: Eighty-five percent of African Americans had cirrhosis on the initial liver biopsy, as compared with 38% of whites. Although not statistically significant, the African Americans presented at an earlier age than white patients. The disease also appeared more advanced in African Americans, as bilibubin levels tended to be higher, but not significantly, and PTs were more prolonged. Both groups responded well to therapy, with significant falls in serum levels of AST, ALT, and bilirubin. Fifty percent of African Americans and 48% of whites entered a biochemical remission. The amount of prednisone required to maintain remission at follow-up was greater in African Americans. CONCLUSION: In contrast to whites, the majority of African Americans present with cirrhosis. Despite the high prevalence of cirrhosis, the response to therapy is good. However, more immunosuppression is required to control the disease in African Americans.

AB - OBJECTIVES: African Americans are at an increased risk for certain diseases and more frequently suffer complications of those diseases relative to their white counterparts. Most studies of autoimmune hepatitis consist of entirely white populations. The Emory University system of hospitals serves a large African American population, including a significant number of African Americans with autoimmune hepatitis. The goal of this study was to determine if the presentation and response to therapy in African Americans is, like other diseases, different than in whites. METHODS: This is a retrospective study from a tertiary referral center that examines the initial presenting features and response to therapy of African Americans (n = 27) and whites (n = 24) with autoimmune hepatitis. RESULTS: Eighty-five percent of African Americans had cirrhosis on the initial liver biopsy, as compared with 38% of whites. Although not statistically significant, the African Americans presented at an earlier age than white patients. The disease also appeared more advanced in African Americans, as bilibubin levels tended to be higher, but not significantly, and PTs were more prolonged. Both groups responded well to therapy, with significant falls in serum levels of AST, ALT, and bilirubin. Fifty percent of African Americans and 48% of whites entered a biochemical remission. The amount of prednisone required to maintain remission at follow-up was greater in African Americans. CONCLUSION: In contrast to whites, the majority of African Americans present with cirrhosis. Despite the high prevalence of cirrhosis, the response to therapy is good. However, more immunosuppression is required to control the disease in African Americans.

UR - http://www.scopus.com/inward/record.url?scp=0035666895&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035666895&partnerID=8YFLogxK

U2 - 10.1016/S0002-9270(01)03834-5

DO - 10.1016/S0002-9270(01)03834-5

M3 - Article

C2 - 11774954

AN - SCOPUS:0035666895

VL - 96

SP - 3390

EP - 3394

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 12

ER -