Automation of the paper-based vertical flow platform for radiation biodosimetry during deep space mission

Jasmine P. Devadhasan, Paul Kuehl, Jerome Lacombe, Jana Stoudemire, Twyman Clements, Jian Gu, Frederic Zenhausern

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Radiation is a main hazard to astronauts, and precise biological approaches for detecting the absorbed dose of space radiation during long deep space missions are currently lacking. Gene expression assay is a promising biodosimetry approach that is less complex than the traditional cytogenetic biodosimetry assays. In this study, we demonstrated detection of radiation sensitive genes using our recently developed paper-based Vertical Flow Platform (VFP) through an immunoassay format. We also designed and prototyped the automation of the VFP module as a point-of-care (POC) monitoring device for ultimate usability of astronauts in space.

Original languageEnglish (US)
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1099-1100
Number of pages2
ISBN (Electronic)9781733419017
StatePublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: Oct 4 2020Oct 9 2020

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period10/4/2010/9/20

Keywords

  • Deep Space Missions
  • Gene Expression
  • Radiation Dosimetry
  • Vertical Flow Platform

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • Chemistry(all)
  • Control and Systems Engineering

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