Autophagy: New insights into its roles in cancer progression and drug resistance

Research output: Contribution to journalEditorialpeer-review

4 Scopus citations

Abstract

Autophagy is a mechanism of lysosomal proteolysis that is utilized to degrade damaged organelles, proteins, and other cellular components. Although key studies demonstrate that autophagy functions as a mechanism of tumor suppression via the degradation of defective pre-malignant cells, autophagy can also be used as a mechanism to break down cellular components under stress conditions to generate the required metabolic materials for cell survival. Autophagy has emerged as an important mediator of resistance to radiation, chemotherapy, and targeted agents. This series of articles highlight the role of autophagy in cancer progression and drug resistance and underscores the need for new and more effective agents that target this process.

Original languageEnglish (US)
Article number3005
Pages (from-to)1-4
Number of pages4
JournalCancers
Volume12
Issue number10
DOIs
StatePublished - Oct 2020

Keywords

  • Autophagy
  • Cancer
  • Drug resistance
  • Lysosome
  • ROC-325

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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