Autophagy regulates ageing in C. elegans

Eszter S. Hars, Haiyan Qi, Alexey G. Ryazanov, Shengkan Jin, Li Cai, Chengcheng Hu, Leroy F. Liu

Research output: Contribution to journalArticle

149 Scopus citations

Abstract

The role of autophagy in ageing regulation has been suggested based on studies in C. elegans, in which knockdown of the expression of bec-1 (ortholog of the yeast and mammalian autophagy genes ATG6/VPS30 and beclin 1, respectively) shortens lifespan of the daf-2(e1370) mutant C. elegans. However, Beclin1/ATG6 is also known to be involved in other cellular functions in addition to autophagy. In the current study, we knocked down two other autophagy genes, atg-7 and atg-12, in C. elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation.

Original languageEnglish (US)
Pages (from-to)93-95
Number of pages3
JournalAutophagy
Volume3
Issue number2
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

Keywords

  • Ageing
  • Autophagy
  • Lifespan
  • atg-12
  • atg-7
  • bec-1
  • daf-2

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Hars, E. S., Qi, H., Ryazanov, A. G., Jin, S., Cai, L., Hu, C., & Liu, L. F. (2007). Autophagy regulates ageing in C. elegans. Autophagy, 3(2), 93-95. https://doi.org/10.4161/auto.3636