Autophagy regulates ageing in C. elegans

Eszter S. Hars, Haiyan Qi, Alexey G. Ryazanov, Shengkan Jin, Li Cai, Chengcheng Hu, Leroy F. Liu

Research output: Contribution to journalArticlepeer-review

156 Scopus citations

Abstract

The role of autophagy in ageing regulation has been suggested based on studies in C. elegans, in which knockdown of the expression of bec-1 (ortholog of the yeast and mammalian autophagy genes ATG6/VPS30 and beclin 1, respectively) shortens lifespan of the daf-2(e1370) mutant C. elegans. However, Beclin1/ATG6 is also known to be involved in other cellular functions in addition to autophagy. In the current study, we knocked down two other autophagy genes, atg-7 and atg-12, in C. elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation.

Original languageEnglish (US)
Pages (from-to)93-95
Number of pages3
JournalAutophagy
Volume3
Issue number2
DOIs
StatePublished - 2007
Externally publishedYes

Keywords

  • Ageing
  • Autophagy
  • Lifespan
  • atg-12
  • atg-7
  • bec-1
  • daf-2

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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