Backbone alignment modeling of the structure-activity relationships of opioid ligands

Zhijun Wu, Victor J. Hruby

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Opioid studies are an important area of modern medicinal chemistry research. In this study we have provided innovative considerations to some long-standing problems in opioid studies, specifically the opioid pharmacophore and the potential binding modes of opioid ligands. Based on a new peptide backbone-alignment concept that we have developed along with this study, we discuss a wide variety of opioid ligands with respect to their structure - activity relationships. (Figure presented).

Original languageEnglish (US)
Pages (from-to)1151-1164
Number of pages14
JournalJournal of Chemical Information and Modeling
Volume51
Issue number5
DOIs
StatePublished - May 23 2011

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Computer Science Applications
  • Library and Information Sciences

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