BAK1, an Arabidopsis LRR receptor-like protein kinase, interacts with BRI1 and modulates brassinosteroid signaling

Jia Li, Jiangqi Wen, Kevin A. Lease, Jason T. Doke, Frans E. Tax, John C. Walker

Research output: Contribution to journalArticlepeer-review

859 Scopus citations

Abstract

Brassinosteroids regulate plant growth and development through a protein complex that includes the leucine-rich repeat receptor-like protein kinase (LRR-RLK) brassinosteroid-insensitive 1 (BRI1). Activation tagging was used to identify a dominant genetic suppressor of bri1, bak1-1D (bri1-associated receptor kinase 1-1Dominant), which encodes an LRR-RLK, distinct from BRI1. Overexpression of BAK1 results in elongated organ phenotypes, while a null allele of BAK1 displays a semidwarfed phenotype and has reduced sensitivity to brassinosteroids (BRs). BAK1 is a serine/threonine protein kinase, and BRI1 and BAK1 interact in vitro and in vivo. Expression of a dominant-negative mutant allele of BAK1 causes a severe dwarf phenotype, resembling the phenotype of null bri1 alleles. These results indicate BAK1 is a component of BR signaling.

Original languageEnglish (US)
Pages (from-to)213-222
Number of pages10
JournalCell
Volume110
Issue number2
DOIs
StatePublished - Jul 26 2002

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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