Basal Forebrain Neurons and Memory: A Biochemical, Histological, and Behavioral Study of Differential Vulnerability to Ibotenate and Quisqualate

Gary L. Wenk, Cheryl A. Harrington, Deborah A. Tucker, Naomi E Rance, Lary C. Walker

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The differential vulnerability of basal forebrain cells to ibotenate (IBO) or quisqualate (QUIS) was investigated in rats. IBO was also coinjected with cystine (CYS) or zinc (Zn). Cortical choline acetyltransferase (ChAT) and glutamate decarboxylase (GAD) activity, neurotensin receptors, and high-affinity choline uptake sites were quantified in conjunction with radioimmunoassays for neurotensin, substance P, and somatostatin; immunocytochemistry for neurotensin-, somatostatin-, Leu-enkephalin-, and ChAT-positive cells; and in situ hybridization histochemistry of somatostatin, substance P, and enkephalin mRNAs. Compared with the performance of controls, continuous alternation performance in a T maze of IBO+Zn or IBO+CYS rats was better than that of IBO rats, whereas the performance of QUIS rats was unimpaired. Of those neurotransmitter systems examined, only ChAT-immunoreactive cells were vulnerable to IBO or QUIS. However, cholinergic cell loss did not correlate with impaired performance.

Original languageEnglish (US)
Pages (from-to)909-923
Number of pages15
JournalBehavioral Neuroscience
Volume106
Issue number6
DOIs
StatePublished - Dec 1992

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Quisqualic Acid
Choline O-Acetyltransferase
Somatostatin
Neurons
Neurotensin
Cystine
Substance P
Zinc
Neurotensin Receptors
Leucine Enkephalin
Glutamate Decarboxylase
Enkephalins
Choline
Cholinergic Agents
Radioimmunoassay
In Situ Hybridization
Neurotransmitter Agents
Immunohistochemistry
Messenger RNA
Basal Forebrain

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Basal Forebrain Neurons and Memory : A Biochemical, Histological, and Behavioral Study of Differential Vulnerability to Ibotenate and Quisqualate. / Wenk, Gary L.; Harrington, Cheryl A.; Tucker, Deborah A.; Rance, Naomi E; Walker, Lary C.

In: Behavioral Neuroscience, Vol. 106, No. 6, 12.1992, p. 909-923.

Research output: Contribution to journalArticle

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