Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves

Yi Zhang, Aaron D. Mickle, Philipp Gutruf, Lisa A. McIlvried, Hexia Guo, Yixin Wu, Judith P. Golden, Yeguang Xue, Jose G. Grajales-Reyes, Xueju Wang, Siddharth Krishnan, Yiwen Xie, Dongsheng Peng, Chun Ju Su, Fengyi Zhang, Jonathan T. Reeder, Sherri K. Vogt, Yonggang Huang, John A. Rogers, Robert W. Gereau

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Studies of the peripheral nervous system rely on controlled manipulation of neuronal function with pharmacologic and/or optogenetic techniques. Traditional hardware for these purposes can cause notable damage to fragile nerve tissues, create irritation at the biotic/abiotic interface, and alter the natural behaviors of animals. Here, we present a wireless, battery-free device that integrates a microscale inorganic light-emitting diode and an ultralow-power microfluidic system with an electrochemical pumping mechanism in a soft platform that can be mounted onto target peripheral nerves for programmed delivery of light and/or pharmacological agents in freely moving animals. Biocompliant designs lead to minimal effects on overall nerve health and function, even with chronic use in vivo. The small size and light weight construction allow for deployment as fully implantable devices in mice. These features create opportunities for studies of the peripheral nervous system outside of the scope of those possible with existing technologies.

Original languageEnglish (US)
Article numbereaaw5296
JournalScience Advances
Volume5
Issue number7
DOIs
StatePublished - Jan 1 2019

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cuffs
mammals
Mammals
nerves
Neurology
peripheral nervous system
electric batteries
Animals
animals
irritation
Microfluidics
Light emitting diodes
Health
Tissue
Hardware
microbalances
health
mice
manipulators
delivery

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)
  • General

Cite this

Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves. / Zhang, Yi; Mickle, Aaron D.; Gutruf, Philipp; McIlvried, Lisa A.; Guo, Hexia; Wu, Yixin; Golden, Judith P.; Xue, Yeguang; Grajales-Reyes, Jose G.; Wang, Xueju; Krishnan, Siddharth; Xie, Yiwen; Peng, Dongsheng; Su, Chun Ju; Zhang, Fengyi; Reeder, Jonathan T.; Vogt, Sherri K.; Huang, Yonggang; Rogers, John A.; Gereau, Robert W.

In: Science Advances, Vol. 5, No. 7, eaaw5296, 01.01.2019.

Research output: Contribution to journalArticle

Zhang, Y, Mickle, AD, Gutruf, P, McIlvried, LA, Guo, H, Wu, Y, Golden, JP, Xue, Y, Grajales-Reyes, JG, Wang, X, Krishnan, S, Xie, Y, Peng, D, Su, CJ, Zhang, F, Reeder, JT, Vogt, SK, Huang, Y, Rogers, JA & Gereau, RW 2019, 'Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves', Science Advances, vol. 5, no. 7, eaaw5296. https://doi.org/10.1126/sciadv.aaw5296
Zhang, Yi ; Mickle, Aaron D. ; Gutruf, Philipp ; McIlvried, Lisa A. ; Guo, Hexia ; Wu, Yixin ; Golden, Judith P. ; Xue, Yeguang ; Grajales-Reyes, Jose G. ; Wang, Xueju ; Krishnan, Siddharth ; Xie, Yiwen ; Peng, Dongsheng ; Su, Chun Ju ; Zhang, Fengyi ; Reeder, Jonathan T. ; Vogt, Sherri K. ; Huang, Yonggang ; Rogers, John A. ; Gereau, Robert W. / Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves. In: Science Advances. 2019 ; Vol. 5, No. 7.
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