Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat

Amay J. Bandodkar, Philipp Gutruf, Jungil Choi, Kun Hyuck Lee, Yurina Sekine, Jonathan T. Reeder, William J. Jeang, Alexander J. Aranyosi, Stephen P. Lee, Jeffrey B. Model, Roozbeh Ghaffari, Chun Ju Su, John P. Leshock, Tyler Ray, Anthony Verrillo, Kyle Thomas, Vaishnavi Krishnamurthi, Seungyong Han, Jeonghyun Kim, Siddharth KrishnanTao Hang, John A. Rogers

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47 Scopus citations

Abstract

Wearable sweat sensors rely either on electronics for electrochemical detection or on colorimetry for visual readout. Non-ideal form factors represent disadvantages of the former, while semiquantitative operation and narrow scope of measurable biomarkers characterize the latter. Here, we introduce a battery-free, wireless electronic sensing platform inspired by biofuel cells that integrates chronometric microfluidic platforms with embedded colorimetric assays. The resulting sensors combine advantages of electronic and microfluidic functionality in a platform that is significantly lighter, cheaper, and smaller than alternatives. A demonstration device simultaneously monitors sweat rate/loss, pH, lactate, glucose, and chloride. Systematic studies of the electronics, microfluidics, and integration schemes establish the key design considerations and performance attributes. Two-day human trials that compare concentrations of glucose and lactate in sweat and blood suggest a potential basis for noninvasive, semi-quantitative tracking of physiological status.

Original languageEnglish (US)
Article numbereaav3294
JournalScience Advances
Volume5
Issue number1
DOIs
StatePublished - Jan 18 2019

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ASJC Scopus subject areas

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Cite this

Bandodkar, A. J., Gutruf, P., Choi, J., Lee, K. H., Sekine, Y., Reeder, J. T., Jeang, W. J., Aranyosi, A. J., Lee, S. P., Model, J. B., Ghaffari, R., Su, C. J., Leshock, J. P., Ray, T., Verrillo, A., Thomas, K., Krishnamurthi, V., Han, S., Kim, J., ... Rogers, J. A. (2019). Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat. Science Advances, 5(1), [eaav3294]. https://doi.org/10.1126/sciadv.aav3294