Beclomethasone dipropionate crystallized from HFA-134a and ethanol

Julie A. Harris, Michael D. Carducci, Paul B. Myrdal

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Beclomethasone dipropionate (BDP) is a long-acting inhaled corticosteroid, used for the treatment of asthma, and as an inhalation therapy with HFA-134a. The sample studied by X-ray crystallography was grown in a mixture of the aerosol propellant HFA-134a, C2H2F4, and 200-proof ethanol. The formula of the crystalline material is C 28H37ClO7·2C2H 6O·C2H2F4. In the crystal structure, disordered solvent occupies a channel which is perpendicular to the BDP molecules. The latter are are stacked together by hydrogen bonding.

Original languageEnglish (US)
Pages (from-to)o1631-o1633
JournalActa Crystallographica Section E: Structure Reports Online
Volume59
Issue number11
DOIs
StatePublished - Nov 1 2003

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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