Benchmark analysis: Shopping with proper confidence

Walter W. Piegorsch, R. Webster West

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We discuss the issue of using benchmark doses for quantifying (excess) risk associated with exposure to environmental hazards. The paradigm of low-dose risk estimation in dose-response modeling is used as the primary application scenario. Emphasis is placed on making simultaneous inferences on benchmark doses when data are in the form of proportions, although the concepts translate easily to other forms of outcome data.

Original languageEnglish (US)
Pages (from-to)913-920
Number of pages8
JournalRisk Analysis
Volume25
Issue number4
DOIs
StatePublished - Aug 1 2005
Externally publishedYes

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Keywords

  • BMD
  • BMDL
  • Benchmark dose
  • Low-dose extrapolation
  • Post hoc comparisons
  • Quantitative risk assessment
  • Simultaneous inferences

ASJC Scopus subject areas

  • Safety, Risk, Reliability and Quality
  • Physiology (medical)

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