Beneficial effects of a novel IH636 grape seed proanthocyanidin extract in the treatment of chronic pancreatitis

Bhaskar Banerjee, Debasis Bagchi

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Oxygen-derived free radicals mediate tissue damage in acute and chronic pancreatitis. Low levels of natural antioxidants in pancreatitis indicate their increased utilization as scavengers of free radicals. Combination therapy with selenium, β-carotene, methionine, and vitamins C and E are known to improve symptoms of chronic and recurrent pancreatitis. This, however, requires many tablets to be taken daily, which is impractical and may reduce compliance. Three patients with chronic pancreatitis (two with a history of alcohol excess and one idiopathic) are reported. Treatment with narcotic analgesics and pancreatic enzyme supplements had failed to control their symptoms. The addition of a commercially available IH636 grape seed proanthocyanidin extract (commercially known as ActiVin) to their treatment regimen led to a reduction in the frequency and intensity of abdominal pain as well as resolution of vomiting in 1 patient.

Original languageEnglish (US)
Pages (from-to)203-206
Number of pages4
JournalDigestion
Volume63
Issue number3
DOIs
StatePublished - May 22 2001
Externally publishedYes

Keywords

  • Abdominal pain
  • Chronic pancreatitis
  • Cyst-jejunostomy
  • Endoscopic retrograde cholangiopancreatography
  • Episode of pain
  • Pancreatic inflammation
  • Proanthocyanidins

ASJC Scopus subject areas

  • Gastroenterology

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