Benign trichogenic tumours: A report of two cases supporting a simplified nomenclature

T. Y. Wong, J. A. Reed, S. Suster, Stuart D Flynn, M. C. Mihm

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We report two cases of a rare benign tumour of hair germ. Clinically, both were solitary, well-circumscribed, subcutaneous nodules located in the extremities. Histologically, the tumours were characterized by nests and thin cords of basaloid epithelial cells intimately associated with a cellular stroma. The basaloid cells exhibited peripheral palisading, keratinization in the form of keratotic cysts and squamoid transformation, and pilar differentiation. An unusual, but distinctive, cibriform pattern of growth was observed. There was no communication with the overlying epidermis. Abundant primitive hair germinal buds and rare more advanced abortive hair follicles were identified. These histological appearances encompass features of both trichoblastic fibroma and trichogenic trichoblastoma, thus distinguishing these neoplasms from other skin tumours and reinforcing the hypothesis that these tumours are closely related from a histogenetic point of view. The presence of overlapping histological features can be problematic for practising histopathologists who rarely encounter these conditions. With this in mind, the term benign trichogenic tumour may be more appropriate to encompass these two tumours and related neoplasms that appear to lie within the spectrum of hair follicle development.

Original languageEnglish (US)
Pages (from-to)575-580
Number of pages6
JournalHistopathology
Volume22
Issue number6
StatePublished - 1993
Externally publishedYes

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Terminology
Neoplasms
Hair Follicle
Fibroma
Skin Neoplasms
Epidermis
Hair
Cysts
Extremities
Epithelial Cells
Growth

Keywords

  • Hair follicle neoplasm
  • Skin
  • Trichogenic tumour

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Wong, T. Y., Reed, J. A., Suster, S., Flynn, S. D., & Mihm, M. C. (1993). Benign trichogenic tumours: A report of two cases supporting a simplified nomenclature. Histopathology, 22(6), 575-580.

Benign trichogenic tumours : A report of two cases supporting a simplified nomenclature. / Wong, T. Y.; Reed, J. A.; Suster, S.; Flynn, Stuart D; Mihm, M. C.

In: Histopathology, Vol. 22, No. 6, 1993, p. 575-580.

Research output: Contribution to journalArticle

Wong, TY, Reed, JA, Suster, S, Flynn, SD & Mihm, MC 1993, 'Benign trichogenic tumours: A report of two cases supporting a simplified nomenclature', Histopathology, vol. 22, no. 6, pp. 575-580.
Wong, T. Y. ; Reed, J. A. ; Suster, S. ; Flynn, Stuart D ; Mihm, M. C. / Benign trichogenic tumours : A report of two cases supporting a simplified nomenclature. In: Histopathology. 1993 ; Vol. 22, No. 6. pp. 575-580.
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