Benzofuran based PDE4 inhibitors

D. G. McGarry, J. R. Regan, F. A. Volz, C. Hulme, K. J. Moriarty, S. W. Djuric, J. E. Souness, B. E. Miller, J. J. Travis, D. M. Sweeney

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Replacement of the 3,4-dialkoxyphenyl substructure common to a number of PDE4 inhibitors with a 2-alkyl-7-methoxybenzofuran unit is described. This substitution can result in either enhancement or substantial reductions in PDE4 inhibitory activity depending on the system to which it is applied. An in vitro SAR study of a potent series of 4-(2-heteroaryl-ethyl)-benzofurans 26 is also presented. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)1131-1139
Number of pages9
JournalBioorganic and Medicinal Chemistry
Volume7
Issue number6
DOIs
StatePublished - Jun 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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