Benzomorphan alkaloids: Natural peptidomimetics of opioid peptide pharmacophores

Andrzej W. Lipkowski, Aleksandra Misicka, Frank Porreca, Peg Davis, Hank I. Yamamura, Dagmar Stropova, Victor J. Hruby

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The synthesis of hybrid analogues of alkaloid nalindol acid and C-terminal fragments of opioid peptides aims to provide the final proof of the proposed topographical relation between opioid peptides and benzomorphan skeleton-containing alkaloids during interaction with receptors. The biological data indicate that the topographical requirements for Tyr1 and Phe4 in opioid peptides are similar for interactions with both δ and κ receptor types.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalLetters in Peptide Science
Volume2
Issue number3-4
DOIs
StatePublished - Nov 1 1995

Keywords

  • Benzomorphan
  • Computer-assisted intuitional analysis
  • Dynorphin
  • Enkephalin
  • Morphinan
  • Opioid
  • Structure-activity relationships

ASJC Scopus subject areas

  • Biochemistry

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