Bepridil: a review of its pharmacology and clinical efficacy as an anti-anginal agent with anti-arrhythmic properties

Joseph S Alpert, P. Coumel, K. Greeff, D. M. Krikler, W. J. Remme, E. Schönbaum, C. W. Verduyn

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Abstract

Bepridil is an anti-anginal agent with a novel chemical structure. Its main pharmacological effects are an increase in coronary blood flow, a reduction in myocardial oxygen demand, reduction in cardiac work, primarily by a decrease in after-load and a dose-dependent negative chronotropic effect, and anti-arrhythmic properties. These are mainly due to a calcium-antagonistic action. There is evidence that fast sodium channels in heart muscle are also inhibited. Trials have shown that bepridil is effective in the prophylactic treatment of various forms of angina pectoris and accompanying arrhythmias. Pharmacokinetic data justify once-daily administration. The evidence suggests that bepridil is generally well tolerated. This paper reviews already published studies and the results of recent investigations on the pharmacological and clinical efficacy of bepridil.

Original languageEnglish (US)
Pages (from-to)195-222
Number of pages28
JournalPharmatherapeutica
Volume4
Issue number4
Publication statusPublished - 1985
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Alpert, J. S., Coumel, P., Greeff, K., Krikler, D. M., Remme, W. J., Schönbaum, E., & Verduyn, C. W. (1985). Bepridil: a review of its pharmacology and clinical efficacy as an anti-anginal agent with anti-arrhythmic properties. Pharmatherapeutica, 4(4), 195-222.