Abstract
Objective: To incrementally improve the use of beryllium lymphocyte proliferation test (LPT) results. Methods: Beryllium BioBank data were analyzed for 532 subjects in three groups: beryllium-exposed, sensitized, or chronic beryllium disease. Predictor variables were LPT stimulation index (SI) at the date of the earliest available data and at the study entry date. RESULTS:: Cross-sectionally, LPT SI magnitude does not distinguish among the three groups. The likelihood of progression from sensitization to disease is associated with the absolute value of SI, but LPT SI interpreted by traditional cut point criteria was not predictive. Conclusions: Updating the criteria for interpreting beryllium LPT data should be considered. Prediction of progression to chronic beryllium disease may be improved by changing the cut point for interpretation or by using the SI as a continuous variable.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 857-860 |
| Number of pages | 4 |
| Journal | Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine |
| Volume | 56 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2014 |
Fingerprint
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Medicine(all)
Cite this
Beryllium BioBank : 2. Lymphocyte proliferation testingx. / Harber, Philip I; Su, Jing; Alongi, Gabriela.
In: Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine, Vol. 56, No. 8, 2014, p. 857-860.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Beryllium BioBank
T2 - 2. Lymphocyte proliferation testingx
AU - Harber, Philip I
AU - Su, Jing
AU - Alongi, Gabriela
PY - 2014
Y1 - 2014
N2 - Objective: To incrementally improve the use of beryllium lymphocyte proliferation test (LPT) results. Methods: Beryllium BioBank data were analyzed for 532 subjects in three groups: beryllium-exposed, sensitized, or chronic beryllium disease. Predictor variables were LPT stimulation index (SI) at the date of the earliest available data and at the study entry date. RESULTS:: Cross-sectionally, LPT SI magnitude does not distinguish among the three groups. The likelihood of progression from sensitization to disease is associated with the absolute value of SI, but LPT SI interpreted by traditional cut point criteria was not predictive. Conclusions: Updating the criteria for interpreting beryllium LPT data should be considered. Prediction of progression to chronic beryllium disease may be improved by changing the cut point for interpretation or by using the SI as a continuous variable.
AB - Objective: To incrementally improve the use of beryllium lymphocyte proliferation test (LPT) results. Methods: Beryllium BioBank data were analyzed for 532 subjects in three groups: beryllium-exposed, sensitized, or chronic beryllium disease. Predictor variables were LPT stimulation index (SI) at the date of the earliest available data and at the study entry date. RESULTS:: Cross-sectionally, LPT SI magnitude does not distinguish among the three groups. The likelihood of progression from sensitization to disease is associated with the absolute value of SI, but LPT SI interpreted by traditional cut point criteria was not predictive. Conclusions: Updating the criteria for interpreting beryllium LPT data should be considered. Prediction of progression to chronic beryllium disease may be improved by changing the cut point for interpretation or by using the SI as a continuous variable.
UR - http://www.scopus.com/inward/record.url?scp=84905907436&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905907436&partnerID=8YFLogxK
U2 - 10.1097/JOM.0000000000000199
DO - 10.1097/JOM.0000000000000199
M3 - Article
C2 - 25099413
AN - SCOPUS:84905907436
VL - 56
SP - 857
EP - 860
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
SN - 1076-2752
IS - 8
ER -