Bidirectional influences between neurons and glial cells in the developing olfactory system

Leslie P Tolbert, Lynne A Oland, Eric S. Tucker, Nicholas J. Gibson, Mark R. Higgins, Brian W. Lipscomb

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Olfactory systems serve as excellent model systems for the study of numerous widespread aspects of neural development and also for the elucidation of features peculiar to the formation of neural circuits specialized to process odor inputs. Accumulated research reveals a fine balance between developmental autonomy of olfactory structures and intercellular interactions essential for their normal development. Recent findings have uncovered evidence for more autonomy than previously realized, but simultaneously have begun to reveal the complex cellular and molecular underpinnings of key interactions among neurons and glial cells at several important steps in olfactory development. Striking similarities in the functional organization of olfactory systems across vertebrate and invertebrate species allow the advantages of different species to be used to address common issues. Our own work in the moth Manduca sexta has demonstrated reciprocal neuron-glia interactions that have key importance in two aspects of development, the sorting of olfactory receptor axons into fascicles targeted for specific glomeruli and the creation of glomeruli. Studies in vertebrate species suggest that similar neuron-glia interactions may underlie olfactory development, although here the roles have not been tested so directly. Similar cellular interactions also are likely to play roles in development of some other systems in which axons of intermixed neurons must sort according to target specificity and systems in which reiterated modules of synaptic neuropil develop.

Original languageEnglish (US)
Pages (from-to)73-105
Number of pages33
JournalProgress in Neurobiology
Volume73
Issue number2
DOIs
StatePublished - Jun 2004

Fingerprint

Neuroglia
Neurons
Axons
Vertebrates
Odorant Receptors
Manduca
Neuropil
Moths
Invertebrates
Research

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bidirectional influences between neurons and glial cells in the developing olfactory system. / Tolbert, Leslie P; Oland, Lynne A; Tucker, Eric S.; Gibson, Nicholas J.; Higgins, Mark R.; Lipscomb, Brian W.

In: Progress in Neurobiology, Vol. 73, No. 2, 06.2004, p. 73-105.

Research output: Contribution to journalArticle

Tolbert, Leslie P ; Oland, Lynne A ; Tucker, Eric S. ; Gibson, Nicholas J. ; Higgins, Mark R. ; Lipscomb, Brian W. / Bidirectional influences between neurons and glial cells in the developing olfactory system. In: Progress in Neurobiology. 2004 ; Vol. 73, No. 2. pp. 73-105.
@article{c52a8d36e9e6423b85182ce1ab9025f5,
title = "Bidirectional influences between neurons and glial cells in the developing olfactory system",
abstract = "Olfactory systems serve as excellent model systems for the study of numerous widespread aspects of neural development and also for the elucidation of features peculiar to the formation of neural circuits specialized to process odor inputs. Accumulated research reveals a fine balance between developmental autonomy of olfactory structures and intercellular interactions essential for their normal development. Recent findings have uncovered evidence for more autonomy than previously realized, but simultaneously have begun to reveal the complex cellular and molecular underpinnings of key interactions among neurons and glial cells at several important steps in olfactory development. Striking similarities in the functional organization of olfactory systems across vertebrate and invertebrate species allow the advantages of different species to be used to address common issues. Our own work in the moth Manduca sexta has demonstrated reciprocal neuron-glia interactions that have key importance in two aspects of development, the sorting of olfactory receptor axons into fascicles targeted for specific glomeruli and the creation of glomeruli. Studies in vertebrate species suggest that similar neuron-glia interactions may underlie olfactory development, although here the roles have not been tested so directly. Similar cellular interactions also are likely to play roles in development of some other systems in which axons of intermixed neurons must sort according to target specificity and systems in which reiterated modules of synaptic neuropil develop.",
author = "Tolbert, {Leslie P} and Oland, {Lynne A} and Tucker, {Eric S.} and Gibson, {Nicholas J.} and Higgins, {Mark R.} and Lipscomb, {Brian W.}",
year = "2004",
month = "6",
doi = "10.1016/j.pneurobio.2004.04.004",
language = "English (US)",
volume = "73",
pages = "73--105",
journal = "Progress in Neurobiology",
issn = "0301-0082",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Bidirectional influences between neurons and glial cells in the developing olfactory system

AU - Tolbert, Leslie P

AU - Oland, Lynne A

AU - Tucker, Eric S.

AU - Gibson, Nicholas J.

AU - Higgins, Mark R.

AU - Lipscomb, Brian W.

PY - 2004/6

Y1 - 2004/6

N2 - Olfactory systems serve as excellent model systems for the study of numerous widespread aspects of neural development and also for the elucidation of features peculiar to the formation of neural circuits specialized to process odor inputs. Accumulated research reveals a fine balance between developmental autonomy of olfactory structures and intercellular interactions essential for their normal development. Recent findings have uncovered evidence for more autonomy than previously realized, but simultaneously have begun to reveal the complex cellular and molecular underpinnings of key interactions among neurons and glial cells at several important steps in olfactory development. Striking similarities in the functional organization of olfactory systems across vertebrate and invertebrate species allow the advantages of different species to be used to address common issues. Our own work in the moth Manduca sexta has demonstrated reciprocal neuron-glia interactions that have key importance in two aspects of development, the sorting of olfactory receptor axons into fascicles targeted for specific glomeruli and the creation of glomeruli. Studies in vertebrate species suggest that similar neuron-glia interactions may underlie olfactory development, although here the roles have not been tested so directly. Similar cellular interactions also are likely to play roles in development of some other systems in which axons of intermixed neurons must sort according to target specificity and systems in which reiterated modules of synaptic neuropil develop.

AB - Olfactory systems serve as excellent model systems for the study of numerous widespread aspects of neural development and also for the elucidation of features peculiar to the formation of neural circuits specialized to process odor inputs. Accumulated research reveals a fine balance between developmental autonomy of olfactory structures and intercellular interactions essential for their normal development. Recent findings have uncovered evidence for more autonomy than previously realized, but simultaneously have begun to reveal the complex cellular and molecular underpinnings of key interactions among neurons and glial cells at several important steps in olfactory development. Striking similarities in the functional organization of olfactory systems across vertebrate and invertebrate species allow the advantages of different species to be used to address common issues. Our own work in the moth Manduca sexta has demonstrated reciprocal neuron-glia interactions that have key importance in two aspects of development, the sorting of olfactory receptor axons into fascicles targeted for specific glomeruli and the creation of glomeruli. Studies in vertebrate species suggest that similar neuron-glia interactions may underlie olfactory development, although here the roles have not been tested so directly. Similar cellular interactions also are likely to play roles in development of some other systems in which axons of intermixed neurons must sort according to target specificity and systems in which reiterated modules of synaptic neuropil develop.

UR - http://www.scopus.com/inward/record.url?scp=2942522580&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942522580&partnerID=8YFLogxK

U2 - 10.1016/j.pneurobio.2004.04.004

DO - 10.1016/j.pneurobio.2004.04.004

M3 - Article

VL - 73

SP - 73

EP - 105

JO - Progress in Neurobiology

JF - Progress in Neurobiology

SN - 0301-0082

IS - 2

ER -