Bifurcation analysis of a mathematical model for malaria transmission

Nakul Chitnis, J. M. Cushing, J. M. Hyman

Research output: Contribution to journalArticlepeer-review

255 Scopus citations

Abstract

We present an ordinary differential equation mathematical model for the spread of malaria in human and mosquito populations. Susceptible humans can be infected when they are bitten by an infectious mosquito. They then progress through the exposed, infectious, and recovered classes, before reentering the susceptible class. Susceptible mosquitoes can become infected when they bite infectious or recovered humans, and once infected they move through the exposed and infectious classes. Both species follow a logistic population model, with humans having immigration and disease-induced death. We define a reproductive number, R0, for the number of secondary cases that one infected individual will cause through the duration of the infectious period. We find that the disease-free equilibrium is locally asymptotically stable when R 0 < 1 and unstable when R0 > 1. We prove the existence of at least one endemic equilibrium point for all R0 > 1. In the absence of disease-induced death, we prove that the transcritical bifurcation at R0 = 1 is supercritical (forward). Numerical simulations show that for larger values of the disease-induced death rate, a subcritical (backward) bifurcation is possible at R0 = 1.

Original languageEnglish (US)
Pages (from-to)24-45
Number of pages22
JournalSIAM Journal on Applied Mathematics
Volume67
Issue number1
DOIs
StatePublished - 2006

Keywords

  • Bifurcation theory
  • Disease-free equilibria
  • Endemic equilibria
  • Epidemic model
  • Malaria
  • Reproductive number

ASJC Scopus subject areas

  • Applied Mathematics

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