Bilateral hippocampal volume predicts verbal memory function in temporal lobe epilepsy

Sheryl L. Reminger, Alfred W Kaszniak, David M Labiner, Lindsey D. Littrell, Brian T. David, T Lee Ryan, Anne M. Herring, Kris L. Kaemingk

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The present study used quantitative volume estimates of the hippocampus based on structural magnetic resonance imaging (MRI) to predict memory performance of individuals with epilepsy of temporal lobe origin (TLE). Twenty individuals with TLE completed standardized neuropsychological tests and a quality of life inventory, and participated in a brain MRI protocol designed to obtain high-resolution images of the hippocampus. The combined volume of the left and right hippocampi was found to be the best predictor of objective verbal memory performance. This finding is consistent with the functional adequacy model of hippocampal function. In contrast, the asymmetry between right and left hippocampal volume was the best predictor of subjective ratings of cognitive functioning, which is consistent with the functional reserve model. The collective and complementary functions of the left and right hippocampi merit further exploration in prospective studies of memory function and TLE.

Original languageEnglish (US)
Pages (from-to)687-695
Number of pages9
JournalEpilepsy and Behavior
Volume5
Issue number5
DOIs
StatePublished - Oct 2004

Fingerprint

Temporal Lobe Epilepsy
Hippocampus
Temporal Lobe
Magnetic Resonance Imaging
Episodic Memory
Neuropsychological Tests
Quality of Life
Prospective Studies
Equipment and Supplies
Brain

Keywords

  • Hippocampus
  • Magnetic resonance imaging
  • Memory
  • Neuropsychology
  • Quality of life
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this

Bilateral hippocampal volume predicts verbal memory function in temporal lobe epilepsy. / Reminger, Sheryl L.; Kaszniak, Alfred W; Labiner, David M; Littrell, Lindsey D.; David, Brian T.; Ryan, T Lee; Herring, Anne M.; Kaemingk, Kris L.

In: Epilepsy and Behavior, Vol. 5, No. 5, 10.2004, p. 687-695.

Research output: Contribution to journalArticle

Reminger, Sheryl L. ; Kaszniak, Alfred W ; Labiner, David M ; Littrell, Lindsey D. ; David, Brian T. ; Ryan, T Lee ; Herring, Anne M. ; Kaemingk, Kris L. / Bilateral hippocampal volume predicts verbal memory function in temporal lobe epilepsy. In: Epilepsy and Behavior. 2004 ; Vol. 5, No. 5. pp. 687-695.
@article{8c836b61678b49898a79dcda5ab12b09,
title = "Bilateral hippocampal volume predicts verbal memory function in temporal lobe epilepsy",
abstract = "The present study used quantitative volume estimates of the hippocampus based on structural magnetic resonance imaging (MRI) to predict memory performance of individuals with epilepsy of temporal lobe origin (TLE). Twenty individuals with TLE completed standardized neuropsychological tests and a quality of life inventory, and participated in a brain MRI protocol designed to obtain high-resolution images of the hippocampus. The combined volume of the left and right hippocampi was found to be the best predictor of objective verbal memory performance. This finding is consistent with the functional adequacy model of hippocampal function. In contrast, the asymmetry between right and left hippocampal volume was the best predictor of subjective ratings of cognitive functioning, which is consistent with the functional reserve model. The collective and complementary functions of the left and right hippocampi merit further exploration in prospective studies of memory function and TLE.",
keywords = "Hippocampus, Magnetic resonance imaging, Memory, Neuropsychology, Quality of life, Temporal lobe epilepsy",
author = "Reminger, {Sheryl L.} and Kaszniak, {Alfred W} and Labiner, {David M} and Littrell, {Lindsey D.} and David, {Brian T.} and Ryan, {T Lee} and Herring, {Anne M.} and Kaemingk, {Kris L.}",
year = "2004",
month = "10",
doi = "10.1016/j.yebeh.2004.06.006",
language = "English (US)",
volume = "5",
pages = "687--695",
journal = "Epilepsy and Behavior",
issn = "1525-5050",
publisher = "Academic Press Inc.",
number = "5",

}

TY - JOUR

T1 - Bilateral hippocampal volume predicts verbal memory function in temporal lobe epilepsy

AU - Reminger, Sheryl L.

AU - Kaszniak, Alfred W

AU - Labiner, David M

AU - Littrell, Lindsey D.

AU - David, Brian T.

AU - Ryan, T Lee

AU - Herring, Anne M.

AU - Kaemingk, Kris L.

PY - 2004/10

Y1 - 2004/10

N2 - The present study used quantitative volume estimates of the hippocampus based on structural magnetic resonance imaging (MRI) to predict memory performance of individuals with epilepsy of temporal lobe origin (TLE). Twenty individuals with TLE completed standardized neuropsychological tests and a quality of life inventory, and participated in a brain MRI protocol designed to obtain high-resolution images of the hippocampus. The combined volume of the left and right hippocampi was found to be the best predictor of objective verbal memory performance. This finding is consistent with the functional adequacy model of hippocampal function. In contrast, the asymmetry between right and left hippocampal volume was the best predictor of subjective ratings of cognitive functioning, which is consistent with the functional reserve model. The collective and complementary functions of the left and right hippocampi merit further exploration in prospective studies of memory function and TLE.

AB - The present study used quantitative volume estimates of the hippocampus based on structural magnetic resonance imaging (MRI) to predict memory performance of individuals with epilepsy of temporal lobe origin (TLE). Twenty individuals with TLE completed standardized neuropsychological tests and a quality of life inventory, and participated in a brain MRI protocol designed to obtain high-resolution images of the hippocampus. The combined volume of the left and right hippocampi was found to be the best predictor of objective verbal memory performance. This finding is consistent with the functional adequacy model of hippocampal function. In contrast, the asymmetry between right and left hippocampal volume was the best predictor of subjective ratings of cognitive functioning, which is consistent with the functional reserve model. The collective and complementary functions of the left and right hippocampi merit further exploration in prospective studies of memory function and TLE.

KW - Hippocampus

KW - Magnetic resonance imaging

KW - Memory

KW - Neuropsychology

KW - Quality of life

KW - Temporal lobe epilepsy

UR - http://www.scopus.com/inward/record.url?scp=15344348414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15344348414&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2004.06.006

DO - 10.1016/j.yebeh.2004.06.006

M3 - Article

C2 - 15380120

AN - SCOPUS:15344348414

VL - 5

SP - 687

EP - 695

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

SN - 1525-5050

IS - 5

ER -