Bilateral symmetry of biomechanical properties in mouse femora

David S. Margolis, Yeong Hau H Lien, Li-Wen Lai, John Szivek

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Bone healing and remodeling are commonly examined in animal models by comparing one femur (experimental) to the contralateral femur (control) with the assumption that they are identical with respect to their biomechanical properties. While past studies have characterized the symmetry in geometrical properties in many types of animal bones, few studies have compared the symmetry in the biomechanical properties. The purpose of this study was to determine whether there is symmetry in the mechanical properties of mouse femora. Strain gauges were attached to the posterior surface of the femora of C57BL/6 mice, parallel to the long axis of the bone. The femora were mechanically tested in cantilever bending while strain values were recorded. Moments of inertia, cortical areas, and moduli of elasticity were determined from strains and cross-sectional properties. Mouse femora demonstrated an average strain difference of 0.4% in tension and 1.4% in compression. Elastic moduli differed by 6.6% and 0.9% in tension and compression, respectively, and failure strength differed by an average of 2.0%. Statistical analysis showed there were no significant differences in strain, modulus, or failure load values for the mice, indicating mechanical and geometrical symmetry of mouse femora in cantilever bending.

Original languageEnglish (US)
Pages (from-to)349-353
Number of pages5
JournalMedical Engineering and Physics
Volume26
Issue number4
DOIs
StatePublished - May 2004

Fingerprint

Femur
Bone
Animals
Elastic moduli
Elastic Modulus
Strain gages
Loads (forces)
Statistical methods
Bone and Bones
Bone Remodeling
Mechanical properties
Inbred C57BL Mouse
Animal Models

Keywords

  • Bilateral symmetry
  • Elastic moduli
  • Failure load
  • Mouse femora
  • Strain

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Psychology(all)

Cite this

Bilateral symmetry of biomechanical properties in mouse femora. / Margolis, David S.; Lien, Yeong Hau H; Lai, Li-Wen; Szivek, John.

In: Medical Engineering and Physics, Vol. 26, No. 4, 05.2004, p. 349-353.

Research output: Contribution to journalArticle

Margolis, David S. ; Lien, Yeong Hau H ; Lai, Li-Wen ; Szivek, John. / Bilateral symmetry of biomechanical properties in mouse femora. In: Medical Engineering and Physics. 2004 ; Vol. 26, No. 4. pp. 349-353.
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