Biliary metabolites and enterohepatic circulation of hexachlorophene in the rat

A. Jay Gandolfi, Donald R. Buhler

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

1. Within 0-5 h after intraperitoneal administration of [14C]hexachlorophene to rats, radioactivity appeared in the bile. Over 2.5-3.0 days, 31% and 47% of administered doses of 5 mg/kg and 10 mg/kg, respectively, were eliminated via this route. 2. Ligation of the bile-duct increased the toxicity of hexachlorophene to rats and also caused the major route of excretion to be via the kidney into the urine (55% of the dose). 3. Extensive enterohepatic circulation of hexachlorophene occurs in the rat. 4. The principal metabolite in bile and in the urine of bile-duct ligated rats was hexachlorophene monoglucuronide, along with small amounts of unchanged drug.

Original languageEnglish (US)
Pages (from-to)693-703
Number of pages11
JournalXenobiotica
Volume4
Issue number11
DOIs
StatePublished - Jan 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Biliary metabolites and enterohepatic circulation of hexachlorophene in the rat'. Together they form a unique fingerprint.

  • Cite this