Binding of Polycitydylic Acid to Graphene Oxide: Spectroscopic Study and Computer Modeling

Maksym V. Karachevtsev, Stepan G. Stepanian, Alexander Yu Ivanov, Victor S. Leontiev, Vladimir A. Valeev, Oksana S. Lytvyn, Ludwik Adamowicz, Victor A. Karachevtsev

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Hybridization of nucleic acids with graphene nanomaterials is of great interest due to its potential application in genosensing and nanomedicine. In this work we study the interaction between polyribocytidylic acid (poly(rC)) and graphene oxide (GO). The study involves comparing the UV absorption spectra of the free polymer and the polymer bonded to graphene oxide and analyzing the vibrational structure of the systems and their components using FTIR spectroscopy. Spectral shifts of the electronic and vibrational bands of the poly(rC) and changes of their thermostability due to the adsorption on GO are observed. Molecular dynamics simulation of the adsorption process of the r(C)10 and r(C)30 oligomers on graphene demonstrates their disordering due to the π-π stacking of cytosines on graphene and shows that the longer oligomer adsorbs slower. The binding energies of a single cytosine stacked with graphene in water and in vacuum were determined. The calculated IR lines of the stacked cytosine with graphene are red-shifted by up to 20 cm-1 compared to free cytosine. A strong decrease of the intensities of the cytosine vibrations in the 1800-1400 cm-1 range resulting from the interaction with graphene is revealed in the spectra. When cytosine is adsorbed to graphene oxide, their complex is additionally stabilized by H-bonding. It leads to an increase of the red shifting of the cytosine lines.

Original languageEnglish (US)
Pages (from-to)18221-18233
Number of pages13
JournalJournal of Physical Chemistry C
Volume121
Issue number33
DOIs
StatePublished - Aug 24 2017

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Oxides
Graphene
graphene
Cytosine
acids
Acids
oxides
oligomers
Oligomers
Polymers
Medical nanotechnology
Adsorption
adsorption
Nucleic acids
polymers
nucleic acids
Binding energy
Nanostructured materials
Nucleic Acids

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Energy(all)
  • Surfaces, Coatings and Films
  • Physical and Theoretical Chemistry

Cite this

Karachevtsev, M. V., Stepanian, S. G., Ivanov, A. Y., Leontiev, V. S., Valeev, V. A., Lytvyn, O. S., ... Karachevtsev, V. A. (2017). Binding of Polycitydylic Acid to Graphene Oxide: Spectroscopic Study and Computer Modeling. Journal of Physical Chemistry C, 121(33), 18221-18233. https://doi.org/10.1021/acs.jpcc.7b04806

Binding of Polycitydylic Acid to Graphene Oxide : Spectroscopic Study and Computer Modeling. / Karachevtsev, Maksym V.; Stepanian, Stepan G.; Ivanov, Alexander Yu; Leontiev, Victor S.; Valeev, Vladimir A.; Lytvyn, Oksana S.; Adamowicz, Ludwik; Karachevtsev, Victor A.

In: Journal of Physical Chemistry C, Vol. 121, No. 33, 24.08.2017, p. 18221-18233.

Research output: Contribution to journalArticle

Karachevtsev, MV, Stepanian, SG, Ivanov, AY, Leontiev, VS, Valeev, VA, Lytvyn, OS, Adamowicz, L & Karachevtsev, VA 2017, 'Binding of Polycitydylic Acid to Graphene Oxide: Spectroscopic Study and Computer Modeling', Journal of Physical Chemistry C, vol. 121, no. 33, pp. 18221-18233. https://doi.org/10.1021/acs.jpcc.7b04806
Karachevtsev MV, Stepanian SG, Ivanov AY, Leontiev VS, Valeev VA, Lytvyn OS et al. Binding of Polycitydylic Acid to Graphene Oxide: Spectroscopic Study and Computer Modeling. Journal of Physical Chemistry C. 2017 Aug 24;121(33):18221-18233. https://doi.org/10.1021/acs.jpcc.7b04806
Karachevtsev, Maksym V. ; Stepanian, Stepan G. ; Ivanov, Alexander Yu ; Leontiev, Victor S. ; Valeev, Vladimir A. ; Lytvyn, Oksana S. ; Adamowicz, Ludwik ; Karachevtsev, Victor A. / Binding of Polycitydylic Acid to Graphene Oxide : Spectroscopic Study and Computer Modeling. In: Journal of Physical Chemistry C. 2017 ; Vol. 121, No. 33. pp. 18221-18233.
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