Binocular Goggle Augmented Imaging and Navigation System provides real-time fluorescence image guidance for tumor resection and sentinel lymph node mapping

Suman B. Mondal, Shengkui Gao, Nan Zhu, Gail P. Sudlow, Kexian Liang, Avik Som, Walter J. Akers, Ryan C. Fields, Julie Margenthaler, Rongguang Liang, Viktor Gruev, Samuel Achilefu

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The inability to identify microscopic tumors and assess surgical margins in real-time during oncologic surgery leads to incomplete tumor removal, increases the chances of tumor recurrence, and necessitates costly repeat surgery. To overcome these challenges, we have developed a wearable goggle augmented imaging and navigation system (GAINS) that can provide accurate intraoperative visualization of tumors and sentinel lymph nodes in real-time without disrupting normal surgical workflow. GAINS projects both near-infrared fluorescence from tumors and the natural color images of tissue onto a head-mounted display without latency. Aided by tumor-targeted contrast agents, the system detected tumors in subcutaneous and metastatic mouse models with high accuracy (sensitivity=100%, specificity=98%±5% standard deviation). Human pilot studies in breast cancer and melanoma patients using a near-infrared dye show that the GAINS detected sentinel lymph nodes with 100% sensitivity. Clinical use of the GAINS to guide tumor resection and sentinel lymph node mapping promises to improve surgical outcomes, reduce rates of repeat surgery, and improve the accuracy of cancer staging.

Original languageEnglish (US)
Article number12117
JournalScientific Reports
Volume5
DOIs
StatePublished - Jul 16 2015

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Eye Protective Devices
Computer Systems
Fluorescence
Neoplasms
Reoperation
Workflow
Sentinel Lymph Node
Neoplasm Staging
Contrast Media
Melanoma
Coloring Agents
Color
Head
Breast Neoplasms
Recurrence
Sensitivity and Specificity

ASJC Scopus subject areas

  • General

Cite this

Binocular Goggle Augmented Imaging and Navigation System provides real-time fluorescence image guidance for tumor resection and sentinel lymph node mapping. / Mondal, Suman B.; Gao, Shengkui; Zhu, Nan; Sudlow, Gail P.; Liang, Kexian; Som, Avik; Akers, Walter J.; Fields, Ryan C.; Margenthaler, Julie; Liang, Rongguang; Gruev, Viktor; Achilefu, Samuel.

In: Scientific Reports, Vol. 5, 12117, 16.07.2015.

Research output: Contribution to journalArticle

Mondal, SB, Gao, S, Zhu, N, Sudlow, GP, Liang, K, Som, A, Akers, WJ, Fields, RC, Margenthaler, J, Liang, R, Gruev, V & Achilefu, S 2015, 'Binocular Goggle Augmented Imaging and Navigation System provides real-time fluorescence image guidance for tumor resection and sentinel lymph node mapping', Scientific Reports, vol. 5, 12117. https://doi.org/10.1038/srep12117
Mondal, Suman B. ; Gao, Shengkui ; Zhu, Nan ; Sudlow, Gail P. ; Liang, Kexian ; Som, Avik ; Akers, Walter J. ; Fields, Ryan C. ; Margenthaler, Julie ; Liang, Rongguang ; Gruev, Viktor ; Achilefu, Samuel. / Binocular Goggle Augmented Imaging and Navigation System provides real-time fluorescence image guidance for tumor resection and sentinel lymph node mapping. In: Scientific Reports. 2015 ; Vol. 5.
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