Bio-MEMS sensors for real-time shear stress on endothelial cell dynamics

Tzung K. Hsiai, Sung K. Cho, Pak K. Wong, Michael Ing, Mohammad Navab, Srinuvasa Reddy, Linda L. Demer, Chih M. Ho

Research output: Contribution to journalConference article

4 Scopus citations

Abstract

Precise characterization of shear stress in the arterial trees is critical to elucidate the effects of spatial versus temporal shear stress gradients on the biological activities of endothelial cells (EC). We developed micro electrical mechanical systems (MEMS) sensors, comparable to the size of EC (2 × 80 μm), to deliver the spatial and temporal resolution necessary at a frequency response > 100 Hz. We provided the first in vitro evidence of real-time wall shear stress on EC couple with real-time gene expression of monocyte chemoattractant protein (MCP-1).

Original languageEnglish (US)
Pages (from-to)1828-1829
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume3
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Keywords

  • Endothelial cells
  • Micro electro mechanical systems (MEMS)
  • Monocytes
  • Shear stress

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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