Bioactive and other piperidine alkaloids from Cassia leptophylla

Vanderlan da S Bolzani, Leslie Gunatilaka, David G I Kingston

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Four new piperidine alkaloids, leptophyllin A (4), 3-acetylleptophyllin A (5), leptophyllin B (8), and (-)-spectaline (1), and 3 known piperidine alkaloids, (-)-spectalinine (2), canavaline (3), and iso-6-canavaline (7), were isolated by a bioassay-guided fractionation of a leaf extract of Cassia leptophylla. The alkaloids 1-3 were active in a mechanism-based DNA-modifying yeast assay and 2 was moderately active in Vero monkey and Chinese hamster ovary cell cytotoxicity assays.

Original languageEnglish (US)
Pages (from-to)5929-5934
Number of pages6
JournalTetrahedron
Volume51
Issue number21
DOIs
StatePublished - May 22 1995
Externally publishedYes

Fingerprint

Cassia
Alkaloids
Assays
Bioassay
Cytotoxicity
Fractionation
Cricetulus
Biological Assay
Yeast
Haplorhini
Ovary
Yeasts
Cells
DNA
piperidine

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Bioactive and other piperidine alkaloids from Cassia leptophylla. / Bolzani, Vanderlan da S; Gunatilaka, Leslie; Kingston, David G I.

In: Tetrahedron, Vol. 51, No. 21, 22.05.1995, p. 5929-5934.

Research output: Contribution to journalArticle

Bolzani, Vanderlan da S ; Gunatilaka, Leslie ; Kingston, David G I. / Bioactive and other piperidine alkaloids from Cassia leptophylla. In: Tetrahedron. 1995 ; Vol. 51, No. 21. pp. 5929-5934.
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